新疆哈萨克族高血压患者外周血T淋巴细胞亚群表达的变化  

Changes of T-lymphocyte Subsets in Peripheral Blood of Hypertension Patients in Xinjiang Kazakh

作　　者：袁庆艳 张源明[2] 张邱兵 章桂铭 郁洁[2] 朱健[2] 

机构地区：[1]山东省菏泽市郓城县人民医院心血管内科,274700 [2]新疆医科大学第一附属医院心脏中心

出　　处：《中国全科医学》2014年第26期3125-3127,共3页Chinese General Practice

基　　金：国家自然科学基金资助项目(81160039);新疆维吾尔自治区自然科学基金资助项目(2010211A41)

摘　　要：目的研究新疆哈萨克族高血压患者外周血T淋巴细胞亚群表达的变化,初步探讨T淋巴细胞亚群表达变化与高血压的关系。方法选取2012年9月—2013年1月新疆医科大学第一附属医院高血压门诊收治的未经降压药物治疗的新疆哈萨克族高血压患者20例作为高血压组,另选取同期在本院体检健康的同民族者20例作为对照组。抽取两组受试者外周静脉血,根据密度梯度离心法提取淋巴细胞,采用流式细胞仪测定CD+3T淋巴细胞、CD+4T淋巴细胞和CD+8T淋巴细胞表达水平。结果对照组CD+3、CD+4、CD+4/CD+8T淋巴细胞表达水平低于高血压组,CD+8T淋巴细胞表达水平高于高血压组(P<0.01)。结论新疆哈萨克族高血压患者存在T淋巴细胞亚群失衡,T淋巴细胞亚群状态异常可能参与高血压的发生发展。Objective To study the changes of T- lymphocyte subsets in peripheral blood of hypertension patients in Xinjiang Kazakh to explore the relationship between T- lymphocyte subsets and hypertension. Methods From September 2012 to January 2013,in the First Hospital Affiliated to Xinjiang Medical University,20 Kazakh hypertension patients who had not treated with antihypertensive drugs were enrolled as study group,another 20 healthy Kazakh subjects were as control group. Peripheral venous blood was drawn to determine the expressions of CD＋3T,CD＋4T and CD＋8T- lymphocytes with flow cytometry（ FCM）. Results The expression levels of CD＋3T,CD＋4T,CD＋4/CD＋8T- lymphocytes were lower and CD＋8T- lymphocytes higher in control group than in study group（ P 〈 0. 01）. Conclusion T- lymphocyte subsets were out of balance in Kazakh hypertensive patients in Xinjiang. Abnormal T- lymphocyte subsets may be involved in the occurrence and development of hypertension.

关 键 词：高血压 炎症 T淋巴细胞 

分 类 号：R544.1[医药卫生—心血管疾病]