早期糖尿病肾病泛素-核糖体融合蛋白52和尿微量清蛋白关系研究  

Relationship of UBA52 with MAU in Patients with Early Diabetic Nephropathy

作　　者：张艳[1] 任荣[1] 梁新华[1] 张蕾[1] 

机构地区：[1]新疆医科大学第五附属医院肾病科,新疆乌鲁木齐市830000

出　　处：《中国全科医学》2014年第26期3128-3130,共3页Chinese General Practice

摘　　要：目的探讨泛素-核糖体融合蛋白52(UBA52)在早期糖尿病肾病(DN)患者中的表达及其与尿微量清蛋白(MAU)的关系。方法选取2012年2月—2013年3月新疆医科大学第五附属医院收治的糖尿病患者20例(糖尿病组),DN患者59例(DN组)。另选取同期在本院体检健康者22例作为对照组。采用免疫透射比浊法检测3组受试者MAU,采用ELISA法检测血UBA52、尿UBA52。结果 3组性别、年龄、BMI比较,差异均无统计学意义(P>0.05);3组血糖、糖化血红蛋白、总胆固醇比较,差异均有统计学意义(P<0.05)。3组血UBA52、尿UBA52、尿蛋白定量和MAU比较,差异均有统计学意义(P<0.05),其中DN组血UBA52、尿UBA52、尿蛋白定量和MAU均高于对照组和糖尿病组,糖尿病组尿蛋白定量、MAU均高于对照组(P<0.05)。多元线性回归分析结果显示,MAU和糖化血红蛋白影响DN患者尿UBA52水平(P<0.05)。结论 DN患者血UBA52、尿UBA52水平升高,MAU是尿UBA52水平的影响因素。Objective To explore the expression of UBA52 and the relationship with MAU in patients with early diabetic nephropathy. Methods 20 diabetes（ diabetic group） and 59 diabetic nephropathy patients（ DN group） admitted by the Fifth Affiliated Hospital of Xinjiang Medical University from February 2012 to March 2013 were selected to be compared with 22 healthy people confirmed by physical check- up in this hospital（ control group）. The immunity transmission turbidity method was used to detect MAU of the three groups and ELISA was used to detect UBA52 in urine and blood. Results The differences of gender,age and BMI of the three groups were not significant（ P 〉 0. 05）; the differences of blood sugar,glycosylated hemoglobin and total cholesterol of the three groups were significant（ P 〈 0. 05）. Blood UBA52,urine UBA52,urinary protein and MAU of the three groups were significantly different（ P 〈 0. 05）; blood,urine UBA52 levels,urinary protein and MAU of DN group were significantly higher than those of another two groups; urinary protein,MAU of diabetic group were significantly higher than those of control group（ P 〈 0. 05）. Multiple linear regression analysis showed that MAU and glycosylated hemoglobin influenced urine UBA52 of DN patients（ P 〈 0. 05）. Conclusion Blood and urine UBA52 levels increase in DN patients. MAU is the influencing factor for urine UBA52 level.

关 键 词：糖尿病肾病 泛素-核糖体融合蛋白52 尿微量清蛋白 

分 类 号：R587.24[医药卫生—内分泌]