婴幼儿毛细支气管炎患者血清IL-13、IL-8、TNF-α、TIgE水平的临床研究  

Clinical Study of Serum IL-13,IL-8,TNF-α,TIgE Level in Children with Bronchiolitis

作　　者：王峻[1] 李峰[1] 王丽[1] 

机构地区：[1]山东大学附属济南市中心医院,山东济南250013

出　　处：《中国医学创新》2014年第27期4-6,共3页Medical Innovation of China

基　　金：山东省医药卫生科技攻关计划(2007HW066)

摘　　要：目的:探讨婴幼儿毛细支气管炎患者血清白细胞介素13(IL-13)、白细胞介素8(IL-8)、肿瘤坏死因子(TNF-α)、TIgE的水平及临床意义。方法:选取36例急性期毛细支气管炎患儿(其中轻症组20例,重症组16例)、30例普通肺炎患儿以及30例同期健康查体儿,采用酶联免疫吸附法ELISA法检测三组的血清IL-13、IL-8、TNF-α、TIgE水平。结果:两组肺炎患儿血清IL-13、IL-8、TNF-α水平均显著高于正常对照组(P<0.05);毛支炎组血清IL-13、IL-8、TNF-α、TIgE均高于普通肺炎组(P<0.05);毛支炎重症组的TNF-α高于轻症组(P<0.05)。结论:IL-13、IL-8、TNF-α参与毛细支气管炎的发病过程,TNF-α水平与毛支炎病情相关,且毛支炎患儿血清TIgE高于正常对照组。Objective：To study the clinical significance on serum level of interleukin 13（IL-13）,interleukin 8（IL-8）,tumor necrosis factor（TNF-α）,TIgE in infants with bronchiolitis. Method：36 cases of infantile with bronchiolitis（20 cases of the mild group and 16 cases of the severe group）,and 30 cases of ordinary pneumonia,with 30 healthy infants were checked for the IL-13,IL-8,TNF-αand TIgE level with ELISA method.Result：The IL-13,IL-8, TNF-αlevel in the two groups of children with bronchiolitis and ordinary pneumonia were significantly higher than that in the normal control group（P〈0.05）;the IL-13,IL-8,TNF-α,TIgE level in the bronchiolitis group were higher than the ordinary pneumonia group（P〈0.05）;the level of TNF-αof the bronchiolitis severe group was higher than that in the mild group（P〈0.05）. Conclusion：IL-13,IL-8,TNF-αlevels play an important role in the process of bronchiolitis, and TNF-αlevel has association with the course and conditions of the disease;the serum level of TIgE is higher in the bronchiolitis infants than that of other control group.

关 键 词：毛细支气管炎 婴幼儿 IL-13 IL-8 TNF-Α TIGE 

分 类 号：R725.6[医药卫生—儿科]