烷基金刚烷甲酸类化合物的合成工艺改进  

Optimization of the synthetic process of alkyl adamantanecarboxylic acids

作　　者：李立锋[1] 刘正[1] 孙业伟[1] 于沛[1] 

机构地区：[1]暨南大学药学院新药研究所,广东广州510632

出　　处：《暨南大学学报（自然科学与医学版）》2014年第5期452-456,共5页Journal of Jinan University(Natural Science & Medicine Edition)

基　　金：国家自然科学基金项目(81302776)

摘　　要：用系列烷基取代的金刚烷化合物与溴素反应，再分别加入草酸钠和水经水解生成相应的烷基金刚烷醇．将该醇与无水甲酸、浓硫酸、CCl4通过Koch-H世aff反应制得1-烷基金刚烷甲酸，总收率达88％～92％，并用质谱和核磁共振谱对所合成化合物进行结构确证．A series of alkyl adamantanecarboxylic acids were perpared from alkyl adamantanes and their process were modified.Starting from alkyl adamantanes,the alkyl adamantanols were obtained after bromination and hydrolysis.Then the alkyl adamantanols underwent a Koch-Haff reaction with anhydrous formic acid and sulfuric acid in CCl_4 to produce 1-alkyl adamantanecarboxylic acids with overall yields of88%-92%.The structures of all products were confirmed by NMR and ESI-MS.

关 键 词：烷基金刚烷 烷基金刚烷醇 1-烷基金刚烷甲酸 Koch-Haff反应 

分 类 号：O629.7[理学—有机化学]