瑞舒伐他汀对高脂诱导肥胖大鼠血清白介素-6水平的影响  

Effects of rosuvastatin on serum IL-6 in high-fat diet-induced obese rats

作　　者：张丽[1] 孙东升[1] 赵湘[2] 谢建洪[1] 

机构地区：[1]浙江省人民医院干部科,杭州市310014 [2]浙江省人民医院肾内科,杭州市310014

出　　处：《心电与循环》2014年第5期393-395,共3页Journal of Electrocardiology and Circulation

基　　金：浙汀省医药卫生科学研究基金计划(2009B018)

摘　　要：目的探讨瑞舒伐他汀对高脂诱导肥胖大鼠的血脂及白介素-6(IL-6)水平的影响。方法将30只雄性大鼠随机分成肥胖组(n=20)和对照组(n=10),分别用高脂饲料和普通饲料饲养14周,然后根据体重增加程度筛选出肥胖大鼠,并分别测定血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)和IL-6的水平。对肥胖组进行瑞舒伐他汀干预,比较其干预前后血脂及IL-6的水平。结果肥胖组大鼠血清TG、TC、LDL-C和IL-6水平均显著高于对照组(均P<0.01),血清IL-6水平与TC、LDL-C呈显著正相关(r=0.72、0 71,均P<0.01);瑞舒伐他汀显著降低肥胖大鼠的血脂及IL-6水平。结论高脂诱导的肥胖大鼠血清IL-6明显升高,瑞舒伐他汀降低血脂的同时,能降低炎症因子IL-6的水平。Objective To evaluate the effects of Rosuvastatin on serum IL- 6 and lipid in high- fat diet- induced obese rats. Methods Thirty male rats were divided into obese（n=20） and control（n=10）groups randomly, and fed a high- fat diet and a standard diet,respectively,for 14 weeks. Obesity was determined based on body weight increment. Serum TC、TG、HDL- C 、LDL- C and IL- 6 were measured. Obese rats were treated with Rosuvastatin. Serum lipid and IL- 6 were compared before and after treatment of Rosuvastatin. Results The levels of serum TG, TC, LDL- C and IL- 6 were significantly higher in obese group than those in the control group（P〈0.01） .The level of IL- 6 was significantly correlated with TC and LDL- C levels （r=0.72、0.71, P〈0.01）. Rosuvastatin significantly decreased serum lipid and IL- 6 of obese rats. Conclusion Serum IL- 6 increases obviously in high- fat diet- induced obese rats. Rosuvastatin could reduce serum IL- 6 as wel as lipid.

关 键 词：肥胖 大鼠 瑞舒伐他汀 白介素- 6 血脂 

分 类 号：R589.2[医药卫生—内分泌]