基于数据挖掘的治疗心房颤动方用药规律分析  

Analysis of Medication Rules of Formulas in Treating Atrial Fibrillation Based on Data Mining

作　　者：鞠建庆[1] 李运伦[2] 杨雯晴[1] 张世君[1] 

机构地区：[1]山东中医药大学 [2]山东中医药大学附属医院,山东济南250011

出　　处：《山东中医药大学学报》2014年第5期432-435,共4页Journal of Shandong University of Traditional Chinese Medicine

基　　金：教育部新世纪优秀人才支持计划(编号:NCET-07-0522)

摘　　要：目的:探索治疗心房颤动中药复方的用药规律。方法:筛选临床研究文献中治疗心房颤动的中药复方,应用频数分析和关联规则算法,对中药复方进行数据挖掘,探讨其核心药物及配伍规律。结果:共筛选中药复方119首,核心药物34味,药对配伍规则20条,药组配伍规则24条,其中炙甘草、麦冬、丹参、五味子、黄芪、当归等为常用核心药物,麦冬-五味子、龙骨-牡蛎、炒酸枣仁-柏子仁、川芎-红花、麦冬-五味子-丹参-炙甘草等为常用配伍组合,苦参、延胡索、甘松为常用抗心律失常中药。结论:益气养阴、安神定志、活血化瘀和专病专药为治疗心房颤动的基本用药规律。Objective：To explore the medication rules of formulas in treating atrial fibrillation by data mining. Methods ：The formulas in treating atrial fibrillation from modern clinical literatures were selected.The data were analyzed by frequency statistics and association rules to find out the medication rules. Results： Total 119 compound herbal formulas were studied. Total 34 frequently used herbs,20 frequently used herb-pairs and 24 frequently used herb-groups were found. Prepared liquoric root,radix ophiopogonis,the root of red-rooted salvia,schisandra chinensis,astragalus membranaceus and angelica sinenisis were the top frequently-used herbs. Radix ophiopogonis-schisandra chinensis, OsDraconis-concha ostreae,Fry zizyphus jujube benevolence-semen boitae, Ligusticum wallichii-Carthamus tinctorius,radix ophiopogonis-schisandra chinensis-the root of red-rooted salvia-prepared liquoric root were the top frequently-used herb-pairs and herb-groups. Radix sophorae flaveseentis-corydalis tuber-rhizoma nardostachyos were the frequently-used antiarrhythmic herbs. Conclusion：Benefiting Qi and nourishing Yin,tranquilizing the mind,promoting blood circulation for removing blood stasis and using special antiarrhythmic herbs were the common medication rules for treating atrial fibrillation.

关 键 词：心房颤动 中药复方 数据挖掘 关联规则 用药规律 

分 类 号：R203[医药卫生—中医学] R289.1