醒脑益智胶囊对乙醇致记忆再现障碍模型小鼠行为学和脑组织SOD、MDA的影响  

Effects of Xingnao Yizhi Capsule on Ethology and SOD,MDA in Brain Tissue of Dysmnesia Mice Induced by Ethanol

作　　者：侯林[1] 张晓平[1] 崔清华[1] 田景振[1] 

机构地区：[1]山东中医药大学,山东济南250355

出　　处：《山东中医药大学学报》2014年第5期475-477,共3页Journal of Shandong University of Traditional Chinese Medicine

基　　金：国家重大新药创制专项(编号:2011ZX09102-003-06)

摘　　要：目的:研究醒脑益智胶囊对乙醇致小鼠记忆再现障碍模型的影响。方法:60只昆明种小鼠随机分为空白对照组,模型组,阳性对照组(石杉碱甲),醒脑益智胶囊高、中、低剂量组,每组10只。灌胃40%乙醇复制小鼠记忆再现障碍模型,跳台试验和避暗试验测定学习记忆能力,同时测定脑组织中超氧化物岐化酶(SOD)活力和丙二醛(MDA)的含量。结果:与模型组比较,醒脑益智胶囊高剂量组能延长小鼠潜伏期,减少5min内错误次数,提高SOD活力,降低MDA的含量,有显著性差异(P<0.05)。结论:醒脑益智胶囊有促进记忆和改善乙醇致小鼠记忆再现障碍的作用。Objective：To study the effects of Xingnao Yizhi capsule on ethology and superoxide dismu tase （SOD）, malonaldehyde （MDA） in brain tissue of dysmnesia mice induced by ethanol. Methods ： Sixty Kunming mice were divided into normal control group,model group,Huperzine-A group,Xingnao Yizhi cap- sule of high dose group,middle dose group and low dose group. There were 10 mice in each group. The memory reproduction disorders model was induced by given 40% ethanol through intragastric administration. Learning and memoring ability of various group rats were assessed with step-through test and step-down test. The content of MDA,activity of SOD in brain tissue were detected. Results：Compared with model group, Xingnao Yizhi capsule of high dose gToup prolonged the latency periods of memo~ , significantly reduced the error times within 5 minutes（P〈0.05）,increased the activity of SOD and decreased the content of MDA in brain tissue（P〈0.05）. Conclusion：Xingnao Yizhi capsule has effects on consolidating learning and memoriz- ing ability of dysmnesia mice induced by ethanol.

关 键 词：醒脑益智胶囊 记忆再现障碍 行为学 超氧化物岐化酶 丙二醛 小鼠 

分 类 号：R285.5[医药卫生—中药学]