SOS应答系统及其对细菌耐药性和毒力的调控作用与在治疗细菌感染中的应用  

Regulation of SOS response to the resistance and virulence of bacteria and its application in the bacterial infection therapy

作　　者：王进文[1,2] 白华[1,2] 颜世敢[1,2] 胡明[1,2] 刘玉庆[1,2] 

机构地区：[1]山东大学农学院,济南250100 [2]山东省农业科学院畜牧兽医研究所,山东省畜禽疫病防控与繁育重点实验室,济南250100

出　　处：《中国抗生素杂志》2014年第10期795-800,共6页Chinese Journal of Antibiotics

基　　金：国家自然基金(81271886);山东省科技发展计划项目(2012GGC02012)

摘　　要：细菌是最简单的细胞生物,却拥有完整的生化过程和完善而富于变化的基因组。如果说中心法则是保证细菌基因组严谨复制和表达的遗传铁律,那么SOS应答(SOS response,SOSr)系统则是细菌长期进化留下的变异窗口,SOSr增加基因组序列的变异,并调控这一庞大基因组有选择地表达和横向交流,以适应多变的环境。很显然,细菌耐药性与致病力也在SOSr系统调控范围内,耐药性或强致病力菌株的出现大大增加了对致病菌感染治疗的难度。因此,认识细菌耐药性和毒力的关系,研究SOSr的调控机制及其抑制措施,具有进化论意义和重要的医疗价值。Bacteria are the simplest cells which has a complete biochemical process and perfect and changeful genome. If the genetic central dogma is the exact law of bacterial genome replication and expression, SOS response（SOSr）is the way of mutation that is remianed in long-time evolution of bacterial, which can increase bacterial mutating frequency, regulates the selective expression of genome and horizontal gene transfer so as to adapt the adverse environment. Absolutely, the resistance and virulence of bacteria are also regulated by SOSr. The emergence of strong resistance and pathogenicity has greatly increased the therapeutical difficulty of pathogenic bacteria infection, so it is essential to discuss the relation of resistance and virulence and research the regulatory mechanism of SOSr to them and the inhibition strategy to SOSr, which has evolutionism significance and important medical application.

关 键 词：SOSr 耐药性 毒力 进化 

分 类 号：R378[医药卫生—病原生物学]