宫颈病变中CD147、MMP-3及TIMP-9表达及临床意义  

Expressions and clinical significance of CD147,MMP-3 and TIMP-9 in cervical lesions

作　　者：傅小一[1] 张子雯[1] 

机构地区：[1]宜春学院医学院病理教研室,江西宜春336000

出　　处：《中国妇幼保健》2014年第29期4742-4744,共3页Maternal and Child Health Care of China

摘　　要：目的:探究宫颈病变中CD147、MMP-3及TIMP-9表达及临床意义。方法:选取宫颈病变样本110例,宫颈上皮病变(CIN)72例,其中CINⅠ16例,CINⅡ21例,CINⅢ35例,宫颈浸润癌38例。采用免疫组化法检测各组样本切片中CD147、MMP-3及TIMP-9的表达量。结果:宫颈癌组CD147 MOD值均明显高于CINⅠ、Ⅱ组和CINⅢ组(P<0.05);宫颈癌样本MMP-3、TIMP-9蛋白含量MOD值与MMP-3/TIMP-9比值均高于另外两组宫颈病变样本(P<0.05);但CINⅢ组与CINⅠ、Ⅱ组二者相比,差异无统计学意义(P>0.05)。结论:CD147蛋白对早期宫颈病变预测、诊断及治疗预后的判断具有重要意义;在宫颈浸润性癌病例中,MMP-3、TIMP-9等生物学指标可能对宫颈病变有效预测。Objective： To explore the expressions and clinical significance of CD147, MMP -3 and TIMP -9 in cervical lesions. Methods： A total of 110 cervical lesions samples were obtained, including 72 samples of cervical intraepithelial lesion （CIN） （16 samples of CIN I , 21 samples of CIN II and 35 samples of CIN III） and 38 samples of invasive cervical cancer. Immunohistochemical method was used to detect the expressions of CD147, MMP - 3 and TIMP - 9 in different groups. Results ： MOD value of CD147 in cervical cancer group was statistically significantly higher than those in CIN I ＋ II group and CIN III group （P 〈 0. 05） ; MOD values of MMP - 3 and TIMP -9 and the ratio of MMP -3/TIMP -9 in cervical cancer group were statistically significantly higher than those in CIN I ＋ Il group and CIN III group （ P 〈 0. 05 ） ; but there was no statistically significant difference between CIN I ＋ II group and CIN III group （P 〉 0.05）. Conclusion： CD147 protein has important significance in predicting diagnosis, treatment and prognosis of early cervical lesions; for the patients with invasive cervical cancer, MMP- 3 and TIMP -9 may be used as predictive biomarkers for cervical lesions.

关 键 词：宫颈病变 CD147 MMP-3 TIMP-9 

分 类 号：R711.74[医药卫生—妇产科学]