宫颈病变中CD147、MMP-3及TIMP-9表达及临床意义  被引量:1

Expressions and clinical significance of CD147,MMP-3 and TIMP-9 in cervical lesions

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作  者:傅小一[1] 张子雯[1] 

机构地区:[1]宜春学院医学院病理教研室,江西宜春336000

出  处:《中国妇幼保健》2014年第29期4742-4744,共3页Maternal and Child Health Care of China

摘  要:目的:探究宫颈病变中CD147、MMP-3及TIMP-9表达及临床意义。方法:选取宫颈病变样本110例,宫颈上皮病变(CIN)72例,其中CINⅠ16例,CINⅡ21例,CINⅢ35例,宫颈浸润癌38例。采用免疫组化法检测各组样本切片中CD147、MMP-3及TIMP-9的表达量。结果:宫颈癌组CD147 MOD值均明显高于CINⅠ、Ⅱ组和CINⅢ组(P<0.05);宫颈癌样本MMP-3、TIMP-9蛋白含量MOD值与MMP-3/TIMP-9比值均高于另外两组宫颈病变样本(P<0.05);但CINⅢ组与CINⅠ、Ⅱ组二者相比,差异无统计学意义(P>0.05)。结论:CD147蛋白对早期宫颈病变预测、诊断及治疗预后的判断具有重要意义;在宫颈浸润性癌病例中,MMP-3、TIMP-9等生物学指标可能对宫颈病变有效预测。Objective: To explore the expressions and clinical significance of CD147, MMP -3 and TIMP -9 in cervical lesions. Methods: A total of 110 cervical lesions samples were obtained, including 72 samples of cervical intraepithelial lesion (CIN) (16 samples of CIN I , 21 samples of CIN II and 35 samples of CIN III) and 38 samples of invasive cervical cancer. Immunohistochemical method was used to detect the expressions of CD147, MMP - 3 and TIMP - 9 in different groups. Results : MOD value of CD147 in cervical cancer group was statistically significantly higher than those in CIN I + II group and CIN III group (P 〈 0. 05) ; MOD values of MMP - 3 and TIMP -9 and the ratio of MMP -3/TIMP -9 in cervical cancer group were statistically significantly higher than those in CIN I + Il group and CIN III group ( P 〈 0. 05 ) ; but there was no statistically significant difference between CIN I + II group and CIN III group (P 〉 0.05). Conclusion: CD147 protein has important significance in predicting diagnosis, treatment and prognosis of early cervical lesions; for the patients with invasive cervical cancer, MMP- 3 and TIMP -9 may be used as predictive biomarkers for cervical lesions.

关 键 词:宫颈病变 CD147 MMP-3 TIMP-9 

分 类 号:R711.74[医药卫生—妇产科学]

 

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