缺血后适应对心肌无复流炎症-氧化应激机制的影响  

The Effect of Postconditioning on the Inflammation-Oxidative Stress of the Myocardiol No-reflow

作　　者：李凤丽[1] 董梅[1] 任法新[1] 

机构地区：[1]青岛大学医学院附属烟台毓璜顶医院心血管内科,山东烟台264000

出　　处：《医学综述》2014年第17期3151-3153,共3页Medical Recapitulate

基　　金：山东省优秀中青年科学家科研奖励基金项目(BS2009YY029)

摘　　要：心肌无复流（MNR）现象是再灌注治疗（包括经皮冠状动脉介入术）后的常见并发症,其发生率为20%~70%,与临床预后密切相关。目前MNR的发生机制尚不明确,大量研究表明炎症-氧化应激参与MNR的发生、发展。缺血后适应具有与缺血预适应类似的心脏保护作用,缺血预适应可以抑制炎症-氧化应激反应。该文主要对心肌无复流的炎症-氧化应激机制及缺血后适应对炎症-氧化应激机制的抑制作用进行综述。The myocardial no reflow （MNR） phenomenon, the incidence of which is 20-70%, is a common complication of the reperfusion therapy （ including percutaneous coronary interention ） , and it is closely related to the clinical prognosis. At present, the mechanism of MNR is unclear, though a large number of studies have shown that inflammation and oxidative stress play a key role in the occurrence, development of MNR. Isehemia posteonditioning could have almost the same heart protection with preconditioning. Studies have shown that isehemie preconditioning can inhibit the inflammation-oxidative stress reaction. Our review will probe into the mechanism of inflammation-oxldative stress of MNR and the inhibition of isehemie postconditioning on inflammation-oxidative stress.

关 键 词：缺血后适应 无复流 炎症-氧化应激 

分 类 号：R542.22[医药卫生—心血管疾病]