非那雄胺预防老年良性前列腺增生患者并发急性尿潴留的影响因素分析  

Analysis on the Influencing Factors of Using Finasteride for Preventing Acute Urinary Retention of Elderly Patients with Benign Prostatic Hyperplasia

作　　者：张洪钦[1] 陈晓文[1] 程文钦[1] 欧阳卫东[1] 赵鹏[1] 

机构地区：[1]解放军421医院老年病科,广州510318

出　　处：《医学综述》2014年第17期3254-3256,共3页Medical Recapitulate

摘　　要：目的探讨影响非那雄胺预防老年良性前列腺增生(BPH)并发急性尿潴留(AUR)的因素。方法收集2004年1月至2009年1月解放军421医院的178例老年BPH患者的临床资料,所有患者均给予非那雄胺治疗,按照是否并发AUR分为AUR组和非AUR组,对可能影响疗效的因素进行单因素和多因素分析。结果两组患者在年龄、糖尿病、吸烟、高血脂及嗜酒等方面比较,差异无统计学意义(P>0.05),在病程、药物疗程、高血压、IPSS评分、最大尿流率、PSA、PV、BMI等方面比较差异具有统计学意义(P<0.05),多因素分析发现PV、病程及药物疗程与非那雄胺的疗效相关。结论非那雄胺预防老年BPH患者并发AUR的疗效受PV、病程及疗程影响,早期、长时间服用非那雄胺的疗效较好。Objective To investigate influencing factors of using finasteride for preventing acute urinary retention（AUR） of elderly patients with benign prostatic hyperplasia （BPH）. Methods A total of 178 elderly patients with benign prostatic hyperplasia admitted in No. 421 Hospital of PLA from Jan. 2004 to Jan. 2009 were all treated with finasteride and divided into AUR group and non-AUR group. Potential influencing factors were analyzed by single factor and multiple factors analysis. Results There was no statistically significant difference in the factors of age, diabetes, smoking, high cholesterol and drinking between the two groups （ P 〉 0.05 ）, but the differences of the course of the disease, drug treatment, high blood pressure, IPSS, maximum urinary flow rate, PSA, PV and BMI between the two groups were statistically significant （ P 〈 0.05 ）. Results of multiple factors analysis showed that factors of PV, course of the disease and course of the treatment were correlated with the effect of finasteride. Conclusion The efficacy of Finasteride in preventing AUR among elderly patients with BPH is influenced by the factors of PV, course of disease and course of treatment,the earlier and longer intake of finasteride,the better the efficacy will be.

关 键 词：非那雄胺 老年良性前列腺增生 急性尿储留 影响因素 

分 类 号：R592[医药卫生—老年医学] R697.31[医药卫生—内科学]