舒巴坦匹酯在肉鸡体内药物动力学研究  

Studies on Pharmacokinetics of Sulbactam Pivoxyl in Broiler

作　　者：何斌[1,2] 操继跃[1] 陈洁 陆征[1] 李在建[1] 杨文海 童新红 江晖[1] 

机构地区：[1]华中农业大学动物医学院,武汉430070 [2]武汉市畜牧兽医科学研究所,武汉430208

出　　处：《中国兽药杂志》2014年第10期32-35,共4页Chinese Journal of Veterinary Drug

摘　　要：本试验主要研究舒巴坦匹酯在肉鸡体内的药物动力学特征和生物利用度,以期为兽医临床用药提供依据。将20羽成年三黄肉鸡随机分成两组,采用单一两期交叉试验设计分别舒巴坦钠静注、舒巴坦匹酯口灌给药,利用高效液相色谱法测定血浆中药物浓度。静脉注射舒巴坦钠(舒巴坦3.75 mg/kg.B.W)后,主要药物动力学参数:t1/2α为0.090±0.001 h,t1/2β为0.919±0.011 h,AUC为6.137±0.376μg·h/mL,CLb为0.611±0.051 L/h/kg。舒巴坦匹酯口灌给药后(舒巴坦3.75 mg/kg.B.W),舒巴坦匹酯主要药动学参数:t1/2ka为0.087±0.007 h,t1/2β为2.044±0.165 h,AUC为4.109±0.364μg·h/mL,Tmax为0.412±0.039 h,Cmax为1.212±0.092μg/mL。肉鸡口灌舒巴坦匹酯后,吸收迅速,分布较快,消除也较快,舒巴坦匹酯的F为66.96%±5.95%。The experiment mainly studied pharmacokinetics and bioavailability of sulbactam pivoxyl in broilers, providing the basis for clinical uses of veterinary drugs. 20 feather adult Sanhuang broilers were randomly divided into two groups, using a single two-period crossover experiment design, respectively by intravenous injection of sulbactam and oral administration of sulbactam pivoxyl, and adopting high performance liquid chromatography to determine concentrations of this drug in plasma. After the intravenous injection of sulbactam sodium （ sulbactam 3.75 mg/kg.B.W）,the main pharmacokinetic parameters were as follows： t1/2αwas 0.090 ± 0.001 h, t1/2β was 0.919 ± 0.011 h, AUC was 6.137 ± 0.376 μg · h/mL, CLb was 0.611 ± 0.051 L/h/kg. And after sulbactam pivoxyl was orally administrated （ sulbactam 3 . 7 5 mg / kg . B . W ） , the major pharmacokinetics parameters of this drug were as follows：t1/2ka was 0.087 ± 0.007 h, t1/2βwas 2.044 ± 0.165 h, AUC was 4.109 ± 0.364μg · h/mL, Tmax was 0.412 ± 0.039 h, Cmax was 1.212 ± 0.092 μg/mL. After oral administration of sulbactam pivoxyl, this drug was absorbed quickly, distributed faster, and also eliminated faster, and the bioavailability of sulbactam pivoxyl was 66.96% ± 5.95%.

关 键 词：舒巴坦 高效液相色谱 肉鸡 药物动力学 

分 类 号：S859.796[农业科学—临床兽医学]