血清脂蛋白和超敏C反应蛋白在2型糖尿病肾病患者血清中的表达及临床意义  

Expression of serum lipoprotein and high sensitivity C-reactive protein in serum of patients with type 2 diabetic nephropathy and its clinical significance

作　　者：侯凤辉 段立志[1] 于莉[1] 吴慧敏[1] 

机构地区：[1]河北港口集团秦皇岛港口医院内分泌科,河北秦皇岛066000

出　　处：《实用临床医药杂志》2014年第17期33-35,共3页Journal of Clinical Medicine in Practice

基　　金：中国高校医学期刊临床专项资金(11321326)

摘　　要：目的探讨血清脂蛋白和超敏C反应蛋白(hs-CRP)水平的变化对2型糖尿病肾病患者的临床意义。方法根据尿白蛋白排泄率(UAER)将174例2型糖尿病患者分为糖尿病无肾病组74例、早期糖尿病肾病组52例、临床糖尿病肾病组48例,以健康体检者60例为对照组,检测各组患者脂蛋白(α)[Lp(α)]、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)以及hs-CRP水平,并分析其血清水平变化与UAER的相关性。结果糖尿病患者各组Lp(α)、hs-CRP水平均高于对照组,且糖尿病患者各组间Lp(α)、hs-CRP水平随着UAER增加而升高,差异有统计学意义(P<0.05);糖尿病患者各组HDLC、LDL-C水平的比较无统计学意义(P>0.05);Lp(α)、hs-CRP分别与UAER呈显著正相关(r=0.8069,0.8989)。结论 Lp(α)、hs-CRP水平与2型糖尿病肾病的发生、发展密切相关,Lp(α)和hs-CRP的检测对2型糖尿病肾病的早期诊断和预后评价具有重要的临床意义。Obj ective To explore the significance of serum lipoprotein and high sensitivity C-reactive protein （hs-CRP）level for the patients with type 2 diabetic nephropathy.Methods 174 patients with type 2 diabetic mellitus were divided into diabetic mellitus group,early diabetic nephropathy group and clinical diabetic nephropathy group,according to the urinary albumin excre-tion rate （UAER）.60 healthy individuals were chosen as control group.Lipoprotein （α）[Lp（α）], high density lipoprotein cholesterol （HDL-C）,low density lipoprotein cholesterol （LDL-C）and hs-CRP were detected,and the results were analyzed statistically.Results The level of Lp （α）, hs-CRP were significantly higher in patients with diabetic mellitus than those in control group （P〈0.05）.Among the three groups with diabetic mellitus,the level of Lp（α）and hs-CRP got progres-sively significant higher with the increase of UAER （P〈0 .05 ）whereas the level of HDL-C and LDL-C did not find significant difference（P〉0 .05 ）.There were linear positive correlation between Lp（α）,hs-CRP and UAER levels（r= 0.8069,0.8989）.Conclusion Lp（α）,hs-CRP levels may be related to the progression of diabetic nephropathy,and their detection had important clinical sig-nificance in early diagnosis and prognostic evaluation of type 2 diabetic nephropathy.

关 键 词：2型糖尿病肾病 血清脂蛋白 超敏C反应蛋白 尿白蛋白排泄率 

分 类 号：R587.1[医药卫生—内分泌]