子痫前期治疗前后血浆NT-proBNP和炎性细胞因子水平的变化  

Changes of plasma NT-proBNP and inflammatory cytokines levels before and after treatment for preeclampsia

作　　者：陈大立[1,2] 许咏梅[1,2] 彭兰[1,2] 杨永青[1,3] 柴利强[1,2] 

机构地区：[1]南京医科大学附属苏州医院 [2]苏州母子医疗保健中心产科,江苏苏州215002 [3]苏州母子医疗保健中心核医学科,江苏苏州215002

出　　处：《实用临床医药杂志》2014年第17期73-75,79,共4页Journal of Clinical Medicine in Practice

摘　　要：目的探讨子痫前期治疗前后血浆N氨基末端脑利钠肽前体(NT-proBNP)和炎性细胞因子水平的变化。方法以荧光免疫分析、放射免疫分析和超敏酶免疫分析法分别测定了93例子痫患者(其中45例轻度和48例重度)血浆中NT-proBNP、IL-6、hs-CRP和TNF-α水平,并与42例正常对照组进行对比分析。结果 93例子痫患者治疗前血浆NT-proBNP、IL-6、hsCRP和TNF-α水平较42例正常对照组明显增高(P均<0.01),并随子痫前期的严重程度而增加。治疗后45例轻度子痫前期患者血浆NT-proBNP、IL-6、hs-CRP和TNF-α水平恢复至正常,48例重度子痫前期患者除血浆中IL-6恢复至正常水平外(P>0.05),血浆NT-proBNP、hs-CRP和TNF-α水平明显降低,但较正常对照组仍增高(P均<0.05)。结论血浆NT-proBNP和炎性细胞因子参与子痫前期发生、发展的病理生理过程,是考核子痫前期治疗的有效指标。Obj ective To explore changes of plasma NT-proBNP and inflamatory cytokines levels before and after treatment for preeclampsia.Methods The levels of NT-proBNP（with fluore-scent immunoassay）and infammatory cytokines（IL-6 ,hs-CRP and TNF-αwith high-sensitive en-zyme immunoassay and radio immunoassay）in plasma were detected in 93 patients with preeclamp-sia （including 45 cases of light pre-eclampsia and 48 cases of severe pre-eclampsia）,and 42 normal people were collected and detected for contrastive analysis.Results Before treatment,the plasma NT-proBNP and inflammatory cytokines （IL-6 ,hs-CRP and TNF-α）levels in 93 patients with preeclampsia were significantly higher than those in 42 normal people （P〈0 .0 1 ）.The plasma NT-proBNP,IL-6,hs-CRP and TNF-αlevels increased with increasing degree of preeclampsia.After treatment,the levels of NT-proBNP,IL-6,hs-CRP and TNF-αin 45 patients with light pre-eclampsia reached to normal level （P〉0 .05 ）.Though the plasma IL-6 level reached to normal lev-el,the levels of NT-proBNP,hs-CRP and TNF-αin 48 patients with severe pre-eclampsia were sig-nificantly higher than those in 42 normal people （P〈0 .05 ）.Conclusion The plasma NT-proBNP and inflammatory cytokines participate in pathogenesis process of preeclampsia,and these two indi-cators are effective monitoring index for the early treatment of preeclampsia.

关 键 词：子痫前期 N氨基末端脑利钠肽前体 炎性细胞因子 有效指标 

分 类 号：R714.24[医药卫生—妇产科学]