甲壳质医用创面贴的临床应用  

Clinical application of chitin medical wound dressing paste

作　　者：张佳[1] 胡素琴[1] 严璐[1] 王桂玲[1] 

机构地区：[1]解放军南京军区南京总医院门诊部,江苏省南京市210002

出　　处：《中国组织工程研究》2014年第34期5555-5560,共6页Chinese Journal of Tissue Engineering Research

摘　　要：背景:甲壳质制备的创面材料具有减轻伤口疼痛、止血、促进伤口愈合作用,并且具有良好的生物相容性和抗菌性,通透性好,能通过体内酶自然降解。目的:对比分析采用甲壳质医用创面贴与常规敷料进行伤口换药处理的临床疗效。方法:纳入临床门诊换药治疗患者60例,按患者意愿分别采用甲壳质医用创面贴和常规敷料换药处理,每组30例。比较两组处理后3,7,14 d伤口愈合率、细菌检出率及目测类比评分,并记录两组的愈合时间和治疗费用。结果与结论:甲壳质医用创面贴组不同时间点伤口愈合率高于常规敷料换药组(P<0.05),不同时间点细菌检出阳性率、目测类比评分低于常规敷料换药组(P<0.05)。甲壳质医用创面贴组窗口愈合时间短于常规敷料换药组(P<0.05)。两组治疗费用比较差异无显著性意义。结果表明采用甲壳质医用创面贴处理创口可以有效促进伤口愈合,降低细菌感染率,患者治疗满意度较优。BACKGROUND：The chitin medical wound dressing can relieve the wound pain, bleeding, and promote wound healing. It has good biocompatibility and antibacterial properties. With the good permeability and natural degradation in the body, it can be used clinicaly as a good biological wound dressing. OBJECTIVE： To evaluate the clinical outcome of the chitin medical wound dressing paste and routine dressings used in changing the dressing and medication. METHODS：We retrospectively studied 60 patients undergoing wound-treatment. They were divided into two groups： chitin medical wound dressing paste group and routine dressing group. Each group had 30 patients. We recorded wound healing rate, detection rate of bacteria, visual analog scale score, healing time and cost of treatment at 3, 7, 14 days after treatment. RESULTS AND CONCLUSION： The wound healing rate, detection rate of bacteria, visual analog scale score, healing time of the chitin medical wound dressing paste group were better than those of the routine dressing change medicine group （P 〈 0.05）. But there was no difference in the cost of treatment between the two groups. Therefore, we can made the conclusion that the chitin medical wound dressing paste used in changing the dressing and medication can promote wound healing, reduce the antibacterial infection rate, and obtain better treatment satisfaction.

关 键 词：生物材料 材料相容性 甲壳质医用创面贴 伤口换药 临床疗效 细菌检出率 抗菌 愈合率 敷料 

分 类 号：R318[医药卫生—生物医学工程]