心绞痛类型与应激性高血压及炎症因子的相关性分析  

Types of angina pectoris are associated with stress-induced hypertension and inflammatory factors

作　　者：李慧[1] 刘薇[1] 李超民[1] 叶明霞[1] 拓步雄[1] 

机构地区：[1]解放军第451医院心血管内科,陕西西安710054

出　　处：《心脏杂志》2014年第5期562-565,共4页Chinese Heart Journal

摘　　要：目的:探讨应激性高血压与心绞痛类型及炎症因子间的相关性。方法:将800例经冠状动脉造影检查确诊的冠心病心绞痛患者分为稳定型心绞痛(SAP)组200例和不稳定型心绞痛(UAP)组600例。所有患者均采用ELISA法测定血清中白细胞介素(IL)-6、IL-8和高敏C反应蛋白(hs-CRP)水平;监测血压≥140/90 mm Hg为高血压。分析冠状动脉造影检查术中血压升高与心绞痛类型及炎症因子的关系。结果:术中血压≥140/90 mm Hg以UAP患者为主,而<140/90 mm Hg以SAP患者为主;UAP患者组血清中IL-6、IL-8和hs-CRP含量均高于SAP组(P<0.05);UAP组中IL-6与hs-CRP呈正相关(r=0.357,P<0.05),WBC与hs-CRP亦呈正相关(r=0.366,P<0.05),SAP组WBC与hs-CRP呈正相关(r=0.521,P<0.05)。结论:应激性高血压可能参与冠状动脉粥样斑块损伤的动态发展过程,其参与方式可能是血管内皮的高炎症反应;因此,应激性高血压可作为预示心绞痛恶化发展的指征之一。AIM： To investigate the relationship of the types of angina pectoris, stress-induced hyperten- sion and inflammatory factors. METHODS： Eight hundred patients with angina diagnosed by coronary angiography were divided into two groups： stable angina pectoris （SAP） group （200 cases） and unstable angina pectoris （UAP） group （600 cases）. The levels of serum IL-6, IL-8 and high-sensitivity C-reactive protein （hs-CRP） were measured using ELISA. Blood pressure was monitored during coronary angiography and patients with stress-induced hypertension were grouped according to blood pressure ≥ 140/90 mmHg during coronary angiography and with normal blood pressure before the procedure. Meanwhile, independent factors that influneed the types of angina pectoris were analyzed by binary logistic regression. RESULTS： During coronary angiography, stress-induced hypertension was mainly detected in patients with UAP, whereas non-stress-induced hypertension was mainly shown in patients with SAP. The levels of serum IL-6, IL-8 and hs-CRP of patients with UAP were markedly higher than those of patients with SAP （P 〈 0. 05）. A group of independent factors including stress-induced hypertension, IL-6, IL-8 and hs-CRP were demonstrated to significantly influence the type of angina pectoris by logistic regression analysis. CONCLUSION： Type of angina pectoris was determined to be associated with stress-induced hypertension as well as inflammatory factors.

关 键 词：心绞痛 高血压 应激 炎症因子 

分 类 号：R541.4[医药卫生—心血管疾病]