衰老影响心肌梗死后心室重构机制研究进展  

Aging heart and post-infarction left ventricular remodeling:research progress

作　　者：罗涛[1] 赵达君[2] 孙阳[3] 

机构地区：[1]第四军医大学航医一队,陕西西安710032 [2]第四军医大学西京医院心血管外科,陕西西安710032 [3]第四军医大学西京医院老年病科,陕西西安710032

出　　处：《心脏杂志》2014年第5期618-620,F0003,共4页Chinese Heart Journal

基　　金：国家自然科学基金项目资助(81100081)

摘　　要：心肌梗死(MI)后病理性心室重构的机制尚未完全明确,目前认为MI后心肌细胞凋亡,受损的心肌细胞自噬以及心肌细胞自我更新能力减低等机制在病理性心室重构中发挥重要作用,最终导致心脏功能降低,在老年人中表现更为突出。随着年龄的增长,心力衰竭(HF)发生率显著增高,亟需深入研究老龄患者心室重构的病理生理改变,为发展靶向治疗老龄患者MI后HF提供理论依据。Pathophysiological changes associated with LV remodeling remain incompletely characterized. Several molecular and cellular processes appear to be particularly important, including ongoing apoptosis of cardiac myocytes, particularly at the border zone of the MI, dysfunctional cardiomyocyte autophagy, and reduction in the proliferative capacity of new cardiomyocytes. This ongoing cell loss and inability to replace lost cells may contribute to the deterioration in cardiac functions. These cardiac changes are particularly pronounced in the elderly. With increasing age, the burden of heart failure is likely to increase. Developing targeted therapies for post-infarction heart failure in the elderly requires investigation into the specific pathophysiological changes of LV remodeling in this age group.

关 键 词：心肌梗死 心室重构 衰老 

分 类 号：R542.2[医药卫生—心血管疾病]