β-半乳糖凝集素3与上皮钙黏蛋白表达在甲状腺不典型腺瘤诊断的意义  

Significance of β-galectin-3 and E-cadherin expressions in diagnosis of atypical thyroid adenoma

作　　者：刘方舟[1] 张园[1] 樊玉文[1] 王玥[1] 赵炎斌[1] 娄可心[2] 虞同华[1] 

机构地区：[1]江苏省肿瘤医院头颈外科,210009 [2]江苏省肿瘤医院病理科,210009

出　　处：《江苏医药》2014年第17期2004-2007,F0002,共5页Jiangsu Medical Journal

摘　　要：目的探讨甲状腺不典型腺瘤的辅助诊断指标。方法采用组织芯片免疫组化法检测40例甲状腺滤泡癌、40例甲状腺腺瘤和40例甲状腺不典型腺瘤组织中β-半乳糖凝集素3(β-galectin-3)和上皮钙黏蛋白(E-cadherin)的表达。结果甲状腺不典型腺瘤组织中β-galectin-3阳性表达率低于甲状腺滤泡癌(52.5%vs.75.0%),但高于甲状腺腺瘤的30.0%(P<0.05);甲状腺不典型腺瘤组织中E-cadherin阳性表达率高于甲状腺滤泡癌(75.0%vs.30.0%),但低于甲状腺腺瘤的87.5%(P<0.05)。结论联合测定β-galectin-3和E-cadherin表达可初步诊断甲状腺不典型腺瘤和甲状腺滤泡癌。Objective To investigate the auxiliary diagnostic indexes used in the diagnosis of atypical thyroid adenoma. Methods Immunohistochemical SP method was used to examine the expressions of β-galectin-3 and E-cadherin in 40 follicular thyroid carcinoma, 40 thyroid adenoma and 40 atypical thyroid adenoma. Results The expression of β-galectin-3 was significantly lower in atypical thyroid adenoma than that in follicular thyroid carcinoma（52.5% vs. 75.0%）, hut higher than 30. 0% in thyroid adenoma（P〈0. 05）. The expression of E-cadherin was significantly higher in atypical thyroid adenoma than that in follicular thyroid carcinoma（75. 0% vs. 30. 0%）, but lower than 87.5% in thyroid adenoma（P〈0. 05）. Conclusion Combined detection β-galectin-3 and E-cadherin is helpful in primary diagnosis of atypical thyroid adenoma and follicular thyroid carcinoma.

关 键 词：β-半乳糖凝集素3 上皮钙黏蛋白 甲状腺不典型腺瘤 甲状腺滤泡癌 

分 类 号：R736[医药卫生—肿瘤]