自体痂皮回植后痂下组织液中炎症介质分析  

Analysis of inflammatory mediators in subeschar tissue fluid after microskin grafting covered by autologous burn eschar

作　　者：苏卫国[1] 娄季鹤[1] 吕涛[1] 李树仁[1] 李延仓[1] 牛希华[1] 吕金龙[1] 

机构地区：[1]郑州市第一人民医院烧伤科,河南郑州450000

出　　处：《河南医学研究》2014年第7期10-13,共4页Henan Medical Research

摘　　要：探讨特重烧伤皮源奇缺患者应用自体痂皮回植和覆盖微粒皮修复深度烧伤创面的安全性.选取2010年11月至2011年9月12例特重烧伤患者,根据微粒皮覆盖物的不同随机分为两组：自体痂皮和异体皮组（A组）和单纯异体皮组（B组）,自体痂皮修复面积占总体表面积（TBSA）的3％ ～11％.比较两组患者术后24 h、48 h、7d的烧伤肢体痂皮和异体皮下组织液中肿瘤坏死因子（TNF-β）、白介素6（IL-6）、白介素8（IL-8）、C反应蛋白（CRP）的表达量,并比较术后第6周肢体烧伤区域的上皮化率. 同一时间点两组患者痂下和异体皮下组织液中TNF-β、IL-6、IL-8、CRP含量无差别,第6周肢体烧伤区域上皮化率差异无统计学意义（P＞0.05）. 经处理的自体痂皮回植不会加重局部炎症反应,应用自体痂皮修复烧伤创面是安全可行的.Objective： To explore the security of microskin grafting covered by autologous burn es- char in the repair of excised severe burn wounds. Methods ： Twelve severely burned patients from November of 2010 to September of 2011 in Department of Burn were randomly divided into two groups based on different coverage of microskin autograft, autologous burn eschar, alloskin （A group, n = 6） and pure alloskin （ B group, n = 6）. The area of autologous burn eschar ranges from 3% to 11% of total body surface area （TBSA）. Local inflammation response was evaluated by the concentration of TNF-β, IL-6, IL-8, CRP in subesehar （A group） or sub-alloskin （B group） tis- sue fluid after microskin grafting. And repair outcomes were compared by skin recovered rate of burned limbs after 6 weeks of microskin autograft. Results ： There were no differences of TNF-[~, IL-6, IL-8 and CRP concentration in subeschar or sub-alloskin tissue fluid, and skin recovered rate of burned limbs after 6 weeks of microskin autograft also had no difference between two groups （ P 〉 0. 05）. Conclusion ： Microskin grafting covered by autologous burn eschar may not lead to lo- cal inflammatory response aggravation, which proved to be a safety substitute material for alloskin.

关 键 词：严重烧伤 痂皮 微粒皮移植 炎症介质 

分 类 号：R644[医药卫生—外科学]