miR-132的生理功能及其在疾病中的作用  

Physiological function of miR-132 and its effects in diseases

作　　者：陈鑫玥[1] 胡雪玲[2] 孙丽华[2] 

机构地区：[1]哈尔滨医科大学,黑龙江哈尔滨150081 [2]哈尔滨医科大学药学院药理学教研室,黑龙江哈尔滨150081

出　　处：《中国医药导报》2014年第29期159-161,164,共4页China Medical Herald

基　　金：国家自然科学基金面上项目(编号81371211)

摘　　要：微小RNA(MicroRNAs)是内源性小分子RNA,通过介导mRNA的降解或抑制其转录,在转录后水平调控基因表达。miR-132成熟序列长度为22 bp,由长度为66 bp的miR-132的前体序列剪切而来。miR-132具有进化保守性,在人、大鼠、小鼠、猿等物种中具有相同的序列与结构。miR-132具有组织特异性,在与神经相关的组织中高表达,参与轴突生长、突触的增殖分化、神经肿瘤的形成等过程。本文进一步明确了miR-132在癌症、神经退行性疾病、精神分裂症、免疫系统疾病等生命过程中所发挥的重要作用。MicroRNAs （miRNAs） is endogenous small RNAs that regulate gene expression at the post-transcriptional level by mediating mRNA degradation or transcriptional inhibition. The length of mature miR-132 sequence is 22 bp, which comes from the 66 bp precursor of miR-132, miR-132 is conserved, which shares the same sequence and structure among human, rat, mouse, miR-132 had tissue specificity, which is highly expressed in nervous tissues, in- volved in axonal growth, proliferation and differentiation of synapses, neural tumor formation process. This review arm to further clarify that miR-132 plays an important role in cancer, neurodegenerative diseases, schizophrenia, immune system diseases.

关 键 词：miR-132 癌症 神经系统疾病 免疫系统疾病 

分 类 号：Q78[生物学—分子生物学]