糖尿病肾病与慢性肾小球肾炎血液透析患者贫血治疗比较  

Renal anemia curative effect of hemodialysis patients of diabetic nephropathy and chronic glomerulonephritis

作　　者：李怡[1] 陈锐[1] 吴国锋[1] 娄爱菊[1] 

机构地区：[1]广州医科大学荔湾医院肾内科,广州510175

出　　处：《广州医药》2014年第5期31-33,共3页Guangzhou Medical Journal

摘　　要：目的通过比较糖尿病肾病与慢性肾小球肾炎导致的CKD5期维持血液透析患者肾性贫血治疗效果,来分析不同病因对肾性贫血治疗的影响。方法我院肾内科CKD5期维持血液透析的原发病为糖尿病肾病和慢性肾小球肾炎的病人,依原发病分为两组:糖尿病肾病组52例和慢性肾小球肾炎组36例,两组均在血液透析后静脉推注重组人促红细胞生成素,每周120 U/kg,治疗1年,对比两组贫血及临床相关指标并分析影响贫血治疗的相关因素。结果糖尿病肾病组较慢性肾小球肾炎组贫血治疗效果差,差异有统计学意义(P<0.05)。空腹血糖、C反应蛋白与血红蛋白呈负相关,尿素清除指数与血红蛋白呈正相关。结论与原发病为慢性肾小球肾炎的血透患者相比,原发病为糖尿病肾病的血透患者对重组人促红细胞生成素的疗效较差,导致疗效差异的原因可能与血糖、炎症、透析充分性等因素有关。Objective This clinical trial was to compare the renal anemia curative effect of maintenance hemodialysis patients of diabetic nephropathy and chronic glomerulonephritis. Methods 52 diabetic nephropathy subjects and 36 chronic glomerulonephritis subjects were given with recombinant human erythropoietin at dosages of 1 20 units by intravenous injection for 1 year. Results Diabetic nephropathy subjects had worse outcome compared with chronic glomerulonephritis.There were neg-ative correlation between fasting blood-glucose,C reactive protein and hemoglobin.There were positive correlation between urea clearance index and hemoglobin. Conclusion Compared with chronic glomerulonephritis subjects,diabetic nephropathy sub-jects had lower responsiveness to erythropoietin.Erythropoietin hyporesponsiveness was possibly related with blood glucose levels, Inflammatory,adequacy.

关 键 词：糖尿病肾病 慢性肾小球肾炎 肾性贫血 重组人促红细胞生成素 

分 类 号：R587.2[医药卫生—内分泌] R692[医药卫生—内科学]