白介素-1β基因rs1143627C/T多态性与2型糖尿病肾病关系探讨  

Relationship Between Interleukin-1β Gene rs1143627-C/T Polymorphism and Type 2 Diabetic Nephropathy

作　　者：王玉霞[1] 边澈[1] 迟希明 赵阳[1] 索琳娜[1] 吴志香[2] 

机构地区：[1]中国医科大学附属第四临床学院内分泌科,辽宁沈阳110032 [2]辽宁中医药大学附属医院内分泌科,辽宁沈阳110032

出　　处：《医学临床研究》2014年第9期1684-1686,共3页Journal of Clinical Research

基　　金：辽宁省科技厅资助项目（编号：2012225019）

摘　　要：[目的]探讨白介素-1β（interleukin-1β,IL-1β）基因rs1143627-C/T多态性与糖尿病肾病（DN）的关系.[方法]应用MassARRAY分子量阵列技术检测132例2型糖尿病（T2DM）合并肾病患者（DN组）,128例T2DM无肾病患者（NDN组）,124例健康对照者（NC组）白介素-1β基因rs1143627-C/T多态性.检测三组研究对象的空腹血糖,血脂等临床指标,并测定体质量指数（BMI）.[结果]DN组与NDN组合T基因型及等位基因T分布频率显著高于NC组,DN组又高于NDN组;DN组与NDN组CC基因型及等位基因C分布频率显著低于NC组,DN组又低于NDN组,差异均有明显统计学意义（P＜0.05）.[结论]IL-1β基因rs1143627-C/T多态性可能与DN的发生有一定关系.[Objective]To explore the correlation between interleukin-1β（IL-1β） gene rs1143627-C/T polymorphism and type 2 diabetic nephropathy（DN）.[Methods]MassARRAY molecular weight array technique was used to detect the polymorphism of IL-1β gene rs1143627-C/T in 132 type 2 diabetic（T2DM） patients with diabetic nephropathy（DN group）,128 T2DM patients without nephropathy（NDN group） and 124 normal controls（NC group）.Fasting blood glucose,blood lipid,body mass index（BMI） and other related clinical indicators in 3 groups were examined.[Results] The distribution frequency of genotype TT,TC and allele T of IL-1β gene rs1143627-C/T in DN group and NDN group were higher than those in NC group,and those in DN group were higher than those in NDN group.The distribution frequency of genotype CC and allele C of IL-1β gene rs1143627-C/T in DN group and NDN group were markedly lower than those in NC group,and those in DN group were lower than those in NDN group.There were significant differences（P ＜0.05）.[Conclusion] IL-1β gene rs1143627-C/T polymorphism may be associated with DN.

关 键 词：白细胞介素1β/遗传学 多态性 单核苷酸 糖尿病 2型/并发症 糖尿病肾病/遗传学 

分 类 号：R587.24[医药卫生—内分泌]