乙螨唑的合成工艺  

Process for the Synthesis of Etoxazole

作　　者：丁成荣[1] 郭欣[1] 张国富[1] 沈俊杰[1] 

机构地区：[1]浙江工业大学化学工程学院,杭州310014

出　　处：《农药》2014年第10期715-717,共3页Agrochemicals

摘　　要：[目的]对乙螨唑的合成工艺进行研究,简化合成方法,提高乙螨唑收率,以满足工业化生产需求。[方法]以2,6-二氟苯甲酰胺为起始原料,经取代反应得到N-(1-甲氧基-2-氯-乙基)-2,6-二氟苯甲酰胺,然后与间叔丁基苯乙醚反应生成相应中间体,最后在氢氧化钠作用下环合得到乙螨唑。目标化合物及中间体结构经1H NMR确证。[结果]反应总收率73.4%,产品含量97.8%。[结论]该工艺收率高,操作简单,经济环保,条件温和,适合工业化生产。[Aims] The purpose of this article is to explore and optimize the synthetic method of the etoxazole, so as to meet the requirement of industrial production. [Methods] The N-（2-chloro-1-methoxyethyl）-2,6-difluorobenzamide can be obtained through substitution reaction using 2,6-difluorobenzamide as starting material, followed by reacting with 1- （tert-butyl）-3-ethoxybenzene to get the corresponding intermediates, finally the etoxazole was obtained through further cyclization. The structures of the product and the intermediates were confirmed by JH NMR. [Results] The total yield was 73.4% and purity was as high as 97.8%. [Conclusions] The synthetic process has advantages of high yield, simple operation, economical and green process, which is suitable for industrial production.

关 键 词：乙螨唑 一锅法 环合 合成 

分 类 号：TQ454[化学工程—农药化工]