血浆同型半胱氨酸与颈动脉斑块稳定性的关系  

The relationship between plasma homocysteine levels and the carotid plague stability in the elderly population

作　　者：杨海娜[1] 李鹤松[2] 杨昕[3] 王伟[4] 

机构地区：[1]天津市第四医院内科,天津300222 [2]天津市人民医院神经外科,天津300121 [3]首都医科大学全科医学与继续教育学院,北京100069 [4]天津市胸科医院心内六科,天津300051

出　　处：《中国实用内科杂志》2014年第10期1012-1014,共3页Chinese Journal of Practical Internal Medicine

基　　金："十二五"国家科技支撑计划(2012BAI37B03)

摘　　要：目的研究中老年人群血浆同型半胱氨酸与颈动脉斑块稳定性的关系。方法 2012年9月1日至2014年4月31日在天津市人民医院神经内科住院患者,符合纳入与排除标准1106例患者为研究对象,评估颈动脉斑块及测量的血浆同型半胱氨酸水平。采用Logistic回归分析血浆同型半胱氨酸与颈动脉斑块稳定性的关系。结果不同性质的颈动脉斑块患者中性别、年龄、高血压史的分布不同(P<0.05)。Logistic回归结果显示,在校正了年龄、性别及高血压等混杂因素后,血浆同型半胱氨酸与颈动脉斑块的稳定性相关。结论中老年人群血浆同型半胱氨酸与颈动脉斑块的稳定性有关,血浆同型半胱氨酸越高发生不稳定性颈动脉斑块的风险越大。Objective To explore the relationship between plasma homocysteine levels and the carotid plaque stability in the elderly population. Methods A total of 1106 outpatients and inpatients with carotid plaque examined by ultrasound examination during September 1 st 2012 to April 31 st 2014 were included. Detected the Plasma homocysteine levels of patients and all of them were examined the carotid plaque by ultrasonography. Logistic regression models were used to assess the associations of homocysteine levels and carotid plaque stability. Results The distributions of gender, age, history of hypertension between the stable and unstable carotid plaques were significantly different. Logistic regression results showed that Plasma homocysteine levels was significantly associated with carotid plaque stability after adjusting for age, sex and other potential confounders. Conclusion Plasma level of homocysteine may be associated with unstable carotid plaque in the elderly population. The higher plasma homocysteine levels, the greater risk of unstable carotid plaque.

关 键 词：中老年人群 同型半胱氨酸 颈动脉斑块 

分 类 号：R543.4[医药卫生—心血管疾病]