老年患者医院获得性肺炎血清可溶性髓系细胞触发受体-1、核转录因子-κB和白细胞介素-8水平变化的研究  

Changes of serum sTREM-1,NF-κB and IL-8 levels in senile patients with hospital-acquired pneumonia

作　　者：王彦蕊[1,2] 张志岷[1,2] 陈瑀[1,2] 滕忠强[1,2] 傅凌玲[1,2] 林娟[1,2] 

机构地区：[1]福建卫生职业技术学院附属医院 [2]福建省级机关医院呼吸科,福建福州350003

出　　处：《中国现代医生》2014年第29期4-6,共3页China Modern Doctor

基　　金：福建省卫生厅青年科研基金(2010-1-29)

摘　　要：目的观察老年患者医院获得性肺炎(HAP)血清可溶性髓系细胞触发受体-1(sTREM-1)及相关炎症因子水平变化,探讨老年HAP患者的全身炎症反应状态。方法 20例老年HAP患者和20例健康体检者,于入组第1、5、10天检测血清sTREM-1、核转录因子-κB(NF-κB)、白细胞介素8(IL-8)的浓度,结合临床肺部感染评分(CPIS)分析上述指标与肺炎严重程度、预后的相关性。结果肺炎组血清sTREM-1、NF-κB、IL-8浓度较对照组显著增高,上述指标与CPIS评分呈正相关。结论 sTREM-1、NF-κB、IL-8是HAP诊断的良好指标,sTREM-1、NF-κB、IL-8水平与HAP的严重程度呈正相关。Objective To observe the changes of soluble triggering receptor expressed on myeloid cell-1 （sTREM-1）and inflammatory mediators in serum of senile patients with hospital-acquired pneumonia and explored the state of local inflammatory response in HAP. Methods Twenty senile patients with HAP and twenty healthy controls were in-cluded. Serum sTREM-1, nuclear factor-κB （NF-κB） and interleukin-8 （IL-8） were detected on day 1, 5, 10. Com-bined with CPIS score to analyze the correlation of these indicators and the severity and prognosis of pneumonia. Re-sults The concentrations of sTREM-1, NF-κB and IL-8 in serum were significantly higher than those in controls. There was a significant positive correlation between the sTREM-1, NF-κB and IL-8 and CPIS score. Conclusion sTREM-1, NF-κB and IL-8 is a good marker in diagnosing pneumonia. The levels of sTREM-1, NF-κB and IL-8 have a positive correlation with severity of HAP.

关 键 词：医院获得性肺炎 可溶性髓系细胞触发受体-1 核转录因子-ΚB 白细胞介素-8 

分 类 号：R563.1[医药卫生—呼吸系统]