七氟醚和异氟醚吸入麻醉对老年患者血清S100B蛋白水平及认知功能的影响  

Influence of sevoflurane and isoflurane inhalation anesthesia on serum S100B protein levels and cognitive function of gerontal patients

作　　者：金超 金鑫 林靖 王琛 

机构地区：[1]浙江省温岭市中医院麻醉科,浙江温岭317500 [2]浙江省温岭市中医院普外科,浙江温岭317500

出　　处：《中国现代医生》2014年第29期35-37,共3页China Modern Doctor

摘　　要：目的探讨七氟醚和异氟醚吸入麻醉对老年患者血清S100B蛋白水平及认知功能的影响。方法选取择期行上腹部手术的老年患者90例,随机分为观察组和对照组,分别予以七氟醚与异氟醚吸入麻醉。观察并比较两组患者麻醉前、麻醉后4、24、48 h血清S100B蛋白水平及认知功能的变化。结果两组患者麻醉后4、24 h血清S100B蛋白水平均较麻醉前明显上升(P<0.05或P<0.01),且对照组上升值明显高于观察组(P<0.05),两组患者麻醉后48 h血清S100B蛋白水平均恢复至麻醉前水平(P>0.05);同时两组患者麻醉后4、24 h MMSE评分均较麻醉前明显下降(P<0.05),且对照组下降值明显大于观察组(P<0.05),两组患者麻醉后48 h时MMSE评分均恢复到麻醉前水平(P>0.05)。结论七氟醚和异氟醚吸入麻醉均能降低老年患者麻醉后早期的认知功能,且七氟醚对认知功能的影响较小,更适合于老年患者,其作用与抑制患者血清S100B蛋白水平上升密切相关。Objective To discuss the influence of sevoflurane and isoflurane inhalation anesthesia on serum S100B Pro-tein levels and cognitive function of gerontal patients. Methods A total of 90 cases of gerontal patients, who were treated with epigastrium operation were selected and divided into observation group and control group randomly, and were given sevoflurane inhalation anesthesia and isoflurane inhalation anesthesia respectively. The changes of serum S100B protein levels and cognitive function of patients in two groups before anesthesia, and 4 hours, 24 hours and 48 hours after the anesthesia were observed and compared. Results The serum S100B protein levels of patients in two groups 4 hours and 24 hours after the anesthesia obviously rose than before （P〈0.05 or P〈0.01）, and the rising rate of patients in control group was much higher than that in observation group （P〈0.05）. The serum S100B protein levels of patients in two groups 48 hours after the anesthesia remained to the same level as those before anesthesia （P〉0.05）. Meanwhile, MMSE scores of patients in two groups 4 hours and 24 hours after the anesthesia obviously declined than before anesthesia （P〈0.05）, and the declining rate of patients in control group was much higher than that in observation group （P〈0.05）. The MMSE scores of patients in two groups 48 hours after the anesthesia remained to the same level as those before anesthesia. Conclusion Both sevoflurane and isoflurane can reduce the early cognitive function of gerontal patients after anesthesia, however, compared with isoflurane, sevoflurane has less influence on the cognitive function of gerontal patients, which is more suitable for gerontal patients and whose mechanism of action has close effect on in-hibiting the rising of serum S100B protein level.

关 键 词：七氟醚 异氟醚 S100B蛋白 认知功能 

分 类 号：R614[医药卫生—麻醉学]