Clinical characteristics of human infection with a novel avian-origin influenza A（H10N8） virus  

作　　者：Zhang Wei Wan Jianguo Qian Kejian Liu Xiaoqing Xiao Zuke Sun Jian Zeng Zhenguo Wang Qi Zhang Jinxiang Jiang Guanghui Nie Cheng Jiang Rong Ding Chengzhi Li Ran Horby Peter Gao Zhancheng 

机构地区：[1]Nanchang University First Affiliated Hospital, Nanchang, Jiangxi 330006, China [2]Nanchang First Hospital, Nanchang, Jiangxi 330008, China [3]Jiangxi Province Center for Disease Control and Prevention,Nanchang, Jiangxi 330038, China [4]Jiangxi Provincial People's Hospital, Nanchang, Jiangxi 330006,China [5]Nanchang University Fourth Affiliated Hospital, Nanchang, Jiangxi 330003, China [6]Chinese Center for Disease Control and Prevention, Beijing 102206,China [7]Department of Respiratory and Critical Care Medicine, PekingUniversity People's Hospital, Beijing 100044, China [8]Oxford University Clinical Research Unit -Wellcome Trust MajorOverseas Programme, Hanoi, Viemam

出　　处：《Chinese Medical Journal》2014年第18期3238-3242,共5页中华医学杂志（英文版）

摘　　要：Background Novel influenza A viruses of avian-origin may be the precursors of pandemic strains. This descriptive study aims to introduce a novel avian-origin influenza A （H10N8） virus which can infect humans and cause severe diseases. Methods Collecting clinical data of three cases of human infection with a novel reassortment avian influenza A （H10N8） virus in Nanchang, Jiangxi Province, China. Results Three cases of human infection with a new reassortment avian influenza A（H10N8） virus were described, of which two were fatal cases, and one was severe case. These cases presented with severe pneumonia that progressed to acute respiratory distress syndrome （ARDS） and intractable respiratory failure. Conclusion This novel reassortment avian influenza A （H10N8） virus in China resulted in fatal human infections, and should be added to concerns in clinical practice.Background Novel influenza A viruses of avian-origin may be the precursors of pandemic strains. This descriptive study aims to introduce a novel avian-origin influenza A （H10N8） virus which can infect humans and cause severe diseases. Methods Collecting clinical data of three cases of human infection with a novel reassortment avian influenza A （H10N8） virus in Nanchang, Jiangxi Province, China. Results Three cases of human infection with a new reassortment avian influenza A（H10N8） virus were described, of which two were fatal cases, and one was severe case. These cases presented with severe pneumonia that progressed to acute respiratory distress syndrome （ARDS） and intractable respiratory failure. Conclusion This novel reassortment avian influenza A （H10N8） virus in China resulted in fatal human infections, and should be added to concerns in clinical practice.

关 键 词：human infection avian influenza A（H10N8） virus REASSORTMENT clinical characteristics 

分 类 号：R511.7[医药卫生—内科学]