住院儿童高尿酸血症发生率及与反映器官损害生化指标的关联性调查  

Investigation on the correlation between incidence rate of high uric acid and biochemical indicators of organ lesions among hospitalized children

作　　者：吴菱[1] 狄亚珍[1] 陈圆玲[1] 钟世玲 何雷[1] 孙楠[1] 

机构地区：[1]浙江省宁波市妇女儿童医院小儿风湿免疫科,315012

出　　处：《中华风湿病学杂志》2014年第9期632-636,共5页Chinese Journal of Rheumatology

基　　金：浙江省宁波市自然科学基金（2014A610280）

摘　　要：目的 探讨住院儿童高尿酸血症水平的分布及其与反映器官损害的生化指标的关联性.方法 回顾性收集2012年6月至2013年10月在浙江省宁波市妇女儿童医院儿内科病房住院的检测过血清尿酸的患儿共23 217例,采用日本Olympus AU 2700生化分析仪检测血生化,其中尿酸酶-过氧化物酶偶联法检测血清尿酸.记录所有患儿的性别、年龄、主要诊断、尿酸水平,其中尿酸水平超过正常范围的患儿2 099例,运用χ2检验比较不同组别高尿酸血症发生率.记录高尿酸血症患儿的各项血生化指标,运用Spearman秩相关对记录生化指标完整的1 650例患儿的血清尿酸与其余各项血生化指标进行相关性分析.结果 ①本院住院儿童高尿酸血症发生率为9.04％（2 099/23 217）,其中男性6.51％（890/13 657）,女性12.65％（1 209/9 560）,性别差异有统计学意义（χ2=256.9,P＜0.05）.②将所有患儿按主要诊断所属系统不同分类,不同系统疾病高尿酸血症发生率依次为危重症36.93％（113/306）,新生儿疾病20.34％（922/4 533）,泌尿系统疾病12.08％ （47/389）,循环系统疾病11.67％（21/180）,神经系统疾病11.05％（112/1 014）,消化系统疾病10.50％（190/1 810）,感染性疾病10.18％（120/1 179）,血液系统疾病7.58％（55/726）,内分泌系统疾病5.74％（17/296）,自身免疫病4.24％（48/1 131）,呼吸系统疾病3.90％（454/11 653）,差异有统计学意义（x2=1423.0,P＜0.05）.③各年龄组高尿酸血症发生率分别为～1个月18.31％（925/5 075）,～1岁4.22％（359/8 501）,～6岁10.68％ （600/5 618）,～15岁5.24％ （211/4 023）,差异有统计学意义（x2=858.5,P＜0.05）,两两比较差异均有统计学意义（P均＜0.05）.④血清尿酸水平与反映肾功能的尿素氮、肌酐及反映心功能的乳酸脱氢酶、α-羟丁酸脱氢酶、CK、CK-MB同工酶水平均呈正相关（r=0.426、0.44、0.324、0.367、0.413、0.431,P均＜0.05）.�Objective To explore the correlation between the distribution of uric acid （UA） level and the biochemical indicators which reflect the degree of organ lesions among hospitalized children.Methods Patients who were hospitalized to the Department of Pediatrics and received the blood UA test from June 2012 to October 2013 were included,23 217 cases in total.The biochemical analyzer-Japan＇s Olympus AU 2700 was used to detect blood biochemistry; and uricase-peroxidase coupling method was used to detect blood UA.Among these patients,2 099 cases whose UA level exceeded the normal level.Then the patients＇ gender,age,primary diagnosis and UA level were recorded; and the distribution of their UA level was described.The Chi-square or Fisher test was used to assess the incidence rate.At the same time,each blood biochemical indicators of the patients with high UA level were recorded ; and the relationships between the blood UA of the 1 650 patients with complete records and each blood biochemical indicator were analyzed with Pearson correlation analysis.Results The incidence rate of hyperuricemia among the hospitalized children was 9.04%（2 099/23 217）.In particular,the incidence rate among boys and girls was 6.5t%（890/13 657） and 12.65% （1 209/9 560） respectively （χ2 =256.9,P〈0.05）.The incidence rate of hyperuricemiin different diseases was as follows：in the critical illness 36.93% （113/306）,neonatal disease 20.34% （922/4 533）,urinary system diseases 12.08% （47/389）,circulatory system diseases 11.67% （21/180）,nervous system diseases 11.05%（112/1 014）,digestive diseases 10.50%（190/1 810）,infectious diseases 10.18%（120/1 179）,blood diseases 7.58% （55/726）,endocrine system diseases 5.74% （17/296）,autoimmune diseases 4.24% （48/1 131）,respiratory diseases 3.90% （454/11 653） respectively （χ2=1423.0,P〈0.05）.The incidence of hyperuricemia at younger than one month was 18.31%（929/5 075）,younger than one year old was 4.22% （359/8 501）,younger than si

关 键 词：高尿酸血症 儿童 住院 婴儿 新生儿 生化指标 

分 类 号：R725.8[医药卫生—儿科]