骨髓干细胞治疗心脏疾病的临床新进展  

Progress on the treatment of cardiovascular disease with bone marrow stem cells

作　　者：赵春梅[1] 王安才[1] 王德国[1] 

机构地区：[1]皖南医学院弋矶山医院老年医学科

出　　处：《中国临床药理学与治疗学》2014年第8期948-952,共5页Chinese Journal of Clinical Pharmacology and Therapeutics

摘　　要：骨髓干细胞为多潜能细胞,包括造血干细胞和间充质干细胞两类,以骨髓组织中含量最为丰富,具有自我更新及多向分化能力,在一定的条件下能被诱导分化为包括心肌细胞在内的多种细胞,可作为理想的种子细胞用于衰老和病变引起的组织器官损伤修复,尤其是应用于心肌梗死、缺血性心衰、难治性心绞痛、扩张型心肌病等心脏疾病的临床治疗。本文就临床骨髓干细胞治疗心脏病的研究报道做简要综述。Bone marrow stem cells are a pop- ulation of multipotent cells, including two types of hematopoietic stem cells and mesenchymal stem cells, which are widely exist in bone mar- row tissue. With the capacity of self-renewal and multiple differentiation, under certain condi- tions ,bone marrow stem cells can be induced to differentiate into a variety of cells including my- ocardial cells and be used as ideal seed cells for tissue and organ damage caused by aging and disease, especially for the clinical treatment ofcardiovascular disease, such as myocardial infarc- tion, ischemic heart failure, intractable angina, dilated cardiomyopathy and so on. The progress on the bone marrow stem cells for the treatment of cardiovascular disease were reviewed in this paper.

关 键 词：骨髓干细胞 心肌梗死 缺血性心衰 难治性心绞痛 扩张型心肌病 

分 类 号：R541.4[医药卫生—心血管疾病]