西格列汀与瑞格列奈在糖尿病肠病患者中的应用效果  

Clinical effects of sitagliptin and repaglinide in glycemic control and gastrointestinal hormone regulation in patientwith diabetic enteropathy

作　　者：徐娜[1] 杨雅如[1] 金文波[1] 

机构地区：[1]南阳市中心医院内分泌科,河南省南阳市473000

出　　处：《世界华人消化杂志》2014年第23期3536-3540,共5页World Chinese Journal of Digestology

摘　　要：目的:观察西格列汀与瑞格列奈对2型糖尿病(diabetes mellitus type 2,T2DM)肠病患者血糖控制和胃肠激素的调节作用效果.方法:将30例门诊糖尿病肠病患者随机分为西格列汀组和瑞格列奈组,每组15例.西格列汀组给予口服磷酸西格列汀100 mg,1次/d,瑞格列奈组给予瑞格列奈片0.5 mg,3次/d,比较服药前后血糖控制效果和胃肠激素水平变化情况.结果:西格列汀组和瑞格列奈组治疗后糖化血红蛋白(hemoglobin A1c)、空腹血糖、餐后2 h血糖(2 h postprandial blood glucose,2 h PBG)均低于治疗前,差异有统计学意义(P<0.05);西格列汀组和瑞格列奈组治疗后血清胃动素(motilin,MTL)、胃泌素(gastrin,GAS)、生长抑素(somatostatin,SS)均低于治疗前,胰高血糖素样肽-1(glucagon-like peptide-1,GLP-1)高于治疗前,差异有统计学意义(P<0.05).治疗后西格列汀组患者MTL和GAS均低于瑞格列奈组,GLP-1高于瑞格列奈组,差异有统计学意义(P<0.05).结论:西格列汀和瑞格列奈均具有良好的控制血糖和促进胃肠功能的作用,西格列汀调节胃肠激素较瑞格列奈效果明显.AIM： To observe the effects of sitagliptin and re-paglinide in glycemic control and gastrointesti-nal hormone regulation in patients with diabetic enteropathy.METHODS： Thirty diabetic enteropathy out-patients were randomly divided into either a repaglinide group or a sitagliptin group,with 15 cases in each group.The sitagliptin group was given sitagliptin phosphate orally 100 mg per day,and the repaglinide group was given repa-glinide 0.5 mg,three times a day.Glycemic con-trol effects and gastrointestinal hormone levels were determined before and after drug adminis-tration.RESULTS： In both the sitagliptin group and re-paglinide group,HbA1 c,fasting plasma glucose,2 h postprandial glucose（2 h PBG） were signifi-cantly lower after treatment than before treat-ment（P〈0.05）.Serum levels of motilin（MTL）,gastrin（GAS）,and somatostatin（SS） were also significantly lower after treatment than before treatment in both groups,while glucagon-like peptide-1（GLP-1） was significantly higher after treatment than before treatment（P〈0.05）.After treatment,serum levels of MTL and GAS were significantly lower,and GLP-1 was significantly higher in the sitagliptin group than in the repa-glinide group（P〈0.05）.CONCLUSION： Sitagliptin and repaglinide have good effects in glycemic control and modulat-ing gastrointestinal function.Ruigelieting has a better effect in regulating gastrointestinal hor-mones.

关 键 词：西格列汀 瑞格列奈 糖尿病肠病 胃肠激素 

分 类 号：R587.2[医药卫生—内分泌]