MicroRNAs对HSC生物学功能的影响  

MicroRNAs and biological functions of hepatic stellate cells

作　　者：毕艺鸣 许嘉彬 安海燕[1] 

机构地区：[1]南方医科大学中医药学院,广东省广州市510515

出　　处：《世界华人消化杂志》2014年第24期3587-3591,共5页World Chinese Journal of Digestology

基　　金：国家级大学生创新创业训练计划基金资助项目;No.201212121053;高等学校博士学科点专项科研基金资助项目;No.20134433120009~~

摘　　要：MicroRNAs(miRNAs)是人体内长约18-24个核苷酸序列的非编码小RNA,通过与mRNA特异性相互作用,调节基因表达,从而调控细胞增殖、分化和凋亡等过程.近年来研究发现,miRNAs可协同转化生长因子(transforming growth factor-β)、核因子κB(nuclear factor-kappa B)、肿瘤坏死因子-α(tumor necrosis factor-α)等细胞因子形成复杂的"网络"信号途径,从而促进肝星形细胞(hepatic stellate cells,HSCs)活化、增殖、迁移和凋亡,提示miRNAs通过各种不同信号转导通路参与调控HSC生物学行为进而影响肝纤维化的发生发展.本文就miRNAs在不同转导通路上对HSC生物学功能的影响作一综述.MicroRNAs（miRNAs） are single-stranded, 18-24 nucleotide long, non-coding RNA molecules which are involved in virtually every cellular process including proliferation, differentiation and apoptosis by specifically interacting with the mRNA and regulating the expression of genes. Recently it has been found that miRNAs cooperate with transforming growth factor（TGF-β）, nuclear factor kappa B（NF-κB）, tumor necrosis factor α（TNF-α） and other cytokines, and form complex ＂network＂ signaling pathways to influence the activation, proliferation, migration and apoptosis of hepatic stellate cells（HSCs）, suggesting that miRNAs may regulate biological behaviors of HSCs via various signal transduction pathways,and have a great influence on the development ofhepatic fibrosis. This article will review the impactof miRNAs on the biological functions of HSCs viadifferent signal transduction pathways.

关 键 词：MICRORNAS 肝纤维化 信号转导 

分 类 号：R3411[医药卫生—基础医学]