磁共振化学位移成像对骨质疏松的诊断价值  

The value of chemical shift MRI for evaluating osteoporosis

作　　者：雷立存[1] 何丽[1] 刘斋[1] 任庆云[1] 

机构地区：[1]河北医科大学第一医院放射科,河北石家庄050031

出　　处：《中国临床医学影像杂志》2014年第9期648-651,共4页Journal of China Clinic Medical Imaging

摘　　要：目的：探讨磁共振化学位移成像对骨质疏松的诊断价值。方法：将70例患者分别按腰椎和髋部骨密度T分数分为骨量正常组、骨量减少组和骨质疏松组,所有患者均行MRI化学位移成像,通过测量MRI化学位移成像中同反相位图像上腰椎1-4椎体的信号强度,计算椎体信号下降指数,分析3组椎体信号下降指数的差异,并同腰椎和髋部骨密度值分别行相关性分析。结果：按照腰椎骨密度分组,正常组、骨量减少组和骨质疏松组的椎体信号下降指数中位数分别是59.73%（21.84%-72.35%）、59.64%（21.55%-78.42%）、57.04%（34.77%-77.30%）,通过两两比较,骨质疏松组与骨量正常组、骨质疏松组与骨量减少组比较,有显著性差异（P〈0.001）,骨量正常组和骨量减少组比较,无显著性差异（P=0.685）。按照髋部骨密度分组,骨量正常组、骨量减少组和骨质疏松组的椎体信号下降指数中位数分别是62.41%（21.84%-77.63%）、58.39%（40.96%-78.42%）、54.76%（21.55%-77.30%）,通过两两比较,三组间均有显著性差异（P〈0.001）,腰椎信号下降指数和髋部骨密度值呈显著正相关（rp=0.351,P=0.004）,腰椎信号下降指数和腰椎骨密度值无显著相关（P=0.379）。结论：MR化学位移成像通过测量椎体信号下降指数能够反映椎体骨髓脂肪含量变化,在骨质疏松的诊断中可能具有较高的临床价值。Objective： To investigate the value of MRI chemical-shift sequences in evaluating fat content of bone marrow for staging of osteoporosis. Materials and Methods： Seventy patients were given dual energy X-ray absorptiometry examination（DXA）, conventional MRI, and chemical shift MRI. According to the T-score of DXA at the lumbar spine and hip, the patients were divided into normal bone density, osteopenia and osteoporosis groups. In order to calculate fat content in bone marrow, the signal intensity of lumbar verbebral bodies（L1-L4） was measured on in-phase and out-of-phase sequences of chemical-shift MRI. Fat content was calculated through signal decline index of the vertebral bodies. The quantitative values were compared with these results of bone density obtained from DXA examination at the lumbar spine and the hip. Correlation analysis was conducted between the signal decline index of the vertebrae and bone density values at lumbar and femoral neck respectively. Results： According to the groups divided by DXA at the spine, the median signal decline index of the vertebral bodies of the 3 groups, normal, osteopenia and osteoporosis groups, was 59.73%（21.84%-72.35%）, 59.64%（21.55%-78.42%）, 57.04%（34.77%-77.30%） respectively. There were statistical differences between osteoporosis and normal group（P〈0.001）, and between the osteoporosis and osteopenia group（P〈0.001）, no statistical difference between normal and osteopenia group（P=0.685）. According to the groups divided by DXA at the hips, the median vertebral signal decline index of the three groups was 62.41%（21.84%-77.63%）, 58.39%（40.96%-78.42%）, and 54.76%（21.55%-77.30%） respectively. There was statistical difference among the groups（P〈0.001）. The signal decline index of lumbar vertebrae was significantly positively correlated to the value of femoral neck bone mineral density（r=0.351, P=0.004）. There was no statistically significant correlation（P=0.379） between the value of lumbar spine mineral de

关 键 词：骨质疏松 磁共振成像 

分 类 号：R681[医药卫生—骨科学] R445.2[医药卫生—外科学]