铜催化微波辅助合成苯并咪唑衍生物的研究  

Copper-Catalyzed Microwave-Assisted Synthesis of Benzimidazole Derivatives

作　　者：柯方[1] 许建华[1] 刘彩琴[1] 黎迁 吴雯 李鹏[1] 

机构地区：[1]福建医科大学药学院,福州350004 [2]厦门市妇幼保健院,厦门361003

出　　处：《有机化学》2014年第9期1900-1904,共5页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.81173096;81202560);福建省自然科学基金(No.2012J05150)资助项目~~

摘　　要：报道了一种简便、高效地构建苯并咪唑衍生物的催化体系.实验发现以廉价的CuI作为催化剂,价廉、易得的8-羟基喹啉为配体,运用微波辅助催化手段,在N,N-二甲基甲酰胺(DMF)中100℃下2-卤代芳胺与脒盐能顺利发生反应生成相应的目标产物,得到中等到优良的产率.A simple, efficient, inexpensive and powerful microwave-assisted method for the Cu-catalyzed reactions of 2-haloanilines with amidines was developed by using cheap CuI as catalyst, inexpensive and readily available 8-hydroxyquinoline as ligand, and N,N-dimethylformamide （DMF） as solvent at 100 ℃. Most target products were obtained in good to excellent yields.

关 键 词：微波辅助合成 2-卤代芳胺 脒盐 苯并咪唑 

分 类 号：O626.23[理学—有机化学]