“江边一碗水”总木脂素的抗肿瘤作用及一般毒性的研究  

Study of the Anti-Tumor Activity and General Toxicity of the Total Lignans of Diphylleia sinensis

作　　者：邓旭坤[1] 蔡爽[1] 蒋捷[1] 陈旅翼[1] 舒广文[1] 林亲雄[1] 梅之南[1] 高康丽 

机构地区：[1]中南民族大学药学院,武汉430074

出　　处：《中南民族大学学报（自然科学版）》2014年第3期57-60,共4页Journal of South-Central University for Nationalities：Natural Science Edition

基　　金：国家科技部"十二五"科技支撑计划资助项目(2012BAI27B06);国家自然科学基金项目资助项目(81073147)

摘　　要：为评价"江边一碗水"总木脂素对H22荷瘤小鼠的肿瘤抑制作用和相关毒性,用SPF级雄性小鼠腋下接种肝癌H22瘤株建立了移植性肝癌H22小鼠模型,观察了不同剂量的"江边一碗水"总木脂素给药10 d后对荷瘤小鼠的肿瘤抑制率、体重、免疫器官指数及血尿常规、肝肾功等的影响.结果表明:50,100,200 mg/kg"江边一碗水"总木脂素的抑瘤率分别为44.9%,54.8%和62.1%."江边一碗水"总木脂素对H22小鼠体重、免疫器官指数、造血系统、肝肾功能等生理生化指标无明显影响.故"江边一碗水"总木脂素具有较显著的抗肿瘤作用和较低的毒性,是其抗肿瘤的药效物质基础.To evaluate the anti-tumor effects of the total lignans of Diphylleia sinensis and its toxicity in hepatocarcinoma H22 solid tumor-bearing mice （ H22 mice ） , the transplanted H 22 hepatocarcinoma mice model was established through axillary vaccination of hepatocarcinoma H 22 cells to SPF male mice . Different dosages of Diphylleia sinensis were administrated for 10 d to H22 mice to evaluate its tumor inhibitory effect as well as the effects on body weight , immune organ index, blood and urine routine ,liver and renal function , et al.The results indicated that the tumor inhibitiory rates of 50, 100, 200 mg/kg total lignans of Diphylleia sinensis were 44.9%, 54.8%, 62.1%respectively, but the administration had no obvious effect on the body weight , immune organ index , hematopoietic system , liver and renal function .So the total lignans of Diphylleia sinensis had obvious anti-tumor effect but had low toxicity , which was probably the anti-tumor basis of Diphylleia sinensis.

关 键 词：江边一碗水 木脂素 抗肿瘤 药效物质基础 H22肝癌荷瘤小鼠 

分 类 号：R285.5[医药卫生—中药学]