内皮素-1前体肽在CAP患者严重程度及预后中的价值  

Value of endothelin-1 precursor peptides in evaluating the severity and prognosis of CAP

作　　者：周锦桃[1] 孙异锋[1] 

机构地区：[1]苏州大学附属太仓医院呼吸内科,江苏苏州251400

出　　处：《临床肺科杂志》2014年第11期1944-1947,共4页Journal of Clinical Pulmonary Medicine

基　　金：苏州市2012年度科技发展计划项目(No SYSD2012032)

摘　　要：目的探讨proET-1在评估CAP患者严重程度及预后方面的价值。方法对我院42例CAP患者进行前瞻性研究,以同期48例健康体检者做对照,根据美国重症肺炎诊断标准,分为重症肺炎组及普通肺炎组,通过统计学处理分析不同组别间proET-1、PCT和白细胞计数差异性。结果 37例普通CAP与5例重症CAP的比较,proET-1及PCT检测有统计学意义(P值分别<0.01和<0.05),而白细胞计数无统计学意义(P值>0.05);42例CAP患者(普通+重症)与对照组比较,proET-1、PCT及白细胞计数的检测均有统计学意义(P值均<0.01);37例普通CAP患者入院时与病情痊愈时(或病情好转时)相比较,白细胞计数及PCT检测有统计学意义(P值分别<0.001和<0.05),而proET-1无统计学意义(P值>0.05)。结论 proET-1及PCT水平和白细胞计数可以作为CAP感染的炎性标记物;proET-1及PCT血浆水平可以预测CAP患者严重程度及预后,且proET-1优于PCT。Objective To investigate the value of endothelin-1 precursor peptides in evaluating the severity and prognosis of CAP. Methods 42 CAP patients were prospectively studied, compared with 48 healthy people as the control group. According to diagnosis standard of severe pneumonia in IDSAZ/ATS, they were divided into the severe pneumonia group and the ordinary pneumonia group. The differences of proET-1, PCT and white cell count were analyzed. Results In 37 cases of ordinary CAP and 5 cases of severe CAP, there was statistical significance in proET-1 and PCT respectively （P〈0. 01 and P〈0. 05）, and there was no significant difference in white blood cell count between the two groups （P〉0. 05）. There were significant differences in proET-1, PCT and blood cell count between the CAP group and the control group （P〈0. 01）. Conclusion ProET-1 and PCT levels and leukocyte count can be used as markers of inflammation of CAP infection. ProET-1 and PCT levels may predict the severity and prognosis of CAP patients, and proET-1 is better than PCT.

关 键 词：内皮素1前体肽 内皮素 社区获得性肺炎 预后 

分 类 号：R563.1[医药卫生—呼吸系统]