糖类抗原CA125与CA19-9联合检测在子宫内膜异位诊断中的临床价值  

Diagnosis value of carbohydrate antigen 125 combined with CA19-9 in detecting endometriosis

作　　者：陶锋[1] 肖传宇[1] 谢强[1] 张光斌[1] 刘峰[1] 闫瑛[1] 汪辉[2] 

机构地区：[1]湖北省枣阳市第一人民医院检验科,湖北枣阳441200 [2]华中科技大学同济医学院附属同济医院妇科,湖北武汉430000

出　　处：《海南医学院学报》2014年第11期1577-1579,共3页Journal of Hainan Medical University

基　　金：湖北省自然科学基金资助项目(编号:2010CDB09403)~~

摘　　要：目的:探讨糖类抗原CA125与CA19-9联合检测在子宫内膜异位症(EMs)诊断中的价值及临床意义。方法:对65例EMs患者、30例卵巢良性肿瘤患者以及55例卵巢上皮癌患者血清CA125、CA19-9水平进行检测,并比较其单项及联合检测的灵敏度、特异性。结果:血清CA125、CA19-9在EMs患者中的浓度及阳性率介于卵巢上皮癌及良性肿瘤患者之间,3组比较差异有统计学意义(P<0.05);血清CA125与CA 19-9联合测定的敏感度显著高于单项检测(P<0.05);70U/mL<CA125<140U/mL诊断EMs的阳性率明显高于卵巢上皮癌及良性肿瘤(P<0.05)。结论:血清CA125与CA19-9联合检测可提高EMs患者的诊断敏感性,CA125以35、140U/mL为临界值有助于区分EMs患者与卵巢良性肿瘤及上皮癌。Objective： To study the diagnosis value of carbohydrate antigen 125 combined with CA19-9 in detection of endometriosis. Methods： The levels of serum CA125, CA19-9 in 65 EMs patients, 30 cases of benign ovarian tumor, 55 cases of epithelial ovarian cancer were detected. The sensitivity, specificity of single detection and combination detection were compared. Results： There were significant differences in serum level and positive rate of CA125, CA19-9 concentration among groups （P（0.05）. The sensitivity of CA125 combined with CA 19-9 was significantly higher than that of single detection （P d0.05）. The positive rate of CA125 in diagnosing ES was significantly higher than in the diagnosis of epithelial ovarian cancer and benign tumors （P〈0.05）. Conclusion： Combined detection of serum CA125 and CA19-9 can improve the sensitivity in diagnosing Ems. CA125 of 35 U/mL, 140 U/mL can be used as critical value to differentiate Ems, benign ovarian tumor and epithelial carcinoma.

关 键 词：子宫内膜异位症 CA125 CA 19-9 敏感性 阳性率 

分 类 号：R711.71[医药卫生—妇产科学]