肺癌化疗老年患者医院感染调查及免疫功能分析  

Analysis of infection and immune function in aged lung cancer patients undergoing chemotherapy in hospital

作　　者：胥桂英[1] 孟月燕[1] 王鲁杰[1] 

机构地区：[1]聊城市人民医院肿瘤科综合Ⅰ病房,山东聊城252000

出　　处：《中华医院感染学杂志》2014年第19期4793-4795,共3页Chinese Journal of Nosocomiology

基　　金：山东省自然科学青年基金资助项目(Q2006C02)

摘　　要：目的研究肺癌化疗老年患者免疫功能和医院感染情况,为临床治疗提供参考依据。方法选取2009年3月-2013年3月在医院进行化疗的老年肺癌患者150例作为研究对象,根据是否出现医院感染分为感染组26例与未感染组124例;对感染组患者的临床资料、病原菌进行分析,并比较两组患者的免疫功能,采用SPSS17.0进行统计分析。结果 150例化疗的老年肺癌患者当中有26例患者发生医院感染,感染率为17.33%,17例患者医院感染发生在化疗后1周以内,感染率65.38%,9例患者发生在化疗后2～4周,感染率34.62%;主要感染部位为上呼吸道占38.46%、下呼吸道占26.92%和胃肠道占15.38%;26例医院感染患者共检出病原菌32株,革兰阴性菌19株,占59.38%,革兰阳性菌9株,占28.12%;真菌4株,占12.50%。结论化疗后患者的免疫功能可能出现不同程度的受损,增加了医院感染的发生风险,可在患者化疗前后给予免疫功能调节治疗和健康干预措施。OBJECTIVE To study the immune function and the status of hospital infection in elderly patients with lung cancer after chemotherapy,to provide the reference for the clinical treatment.METHODS Totally 150 patients with lung cancer from Mar.2009 to Mar.2013 in our hospital were selected as the research subjects,and were divided into the infected group（n=26）and the non-infection group（n=124）according to the presence of hospital infection.The clinical data and pathogens in the infection group were analyzed.The immune function was compared between the two groups of patients.Data were statistically analyzed by SPSS17.0.RESULTS Among the 150 patients,26patients suffered hospital infection,the infection rate was 17.33%.Seventeen cases of hospital infection occurred in 1week after chemotherapy,the infection rate was 65.38%.Nine cases occurred in 2～4weeks after chemotherapy,the infection rate was 34.62%.The main infection sites were upper respiratory tract accounting for 38.46%,lower respiratory tract accounting for 26.92%,and gastrointestinal tract accounting for 15.38%.The 26 patients with hospital infection were found to have a total of 32 strains of pathogenic bacteria,including 19gram-negative bacteria accounting for 59.38%,9gram-positive bacteria accounting for28.12%,4fungi accounting for 12.50%.CONCLUSION Chemotherapy can damage the immune function in different degrees,and increases the risk of hospital infection.Clinician can give immune function adjustment treatment and health intervention measures before and after chemotherapy.

关 键 词：肺癌 化疗 医院感染 免疫功能 

分 类 号：R181.32[医药卫生—流行病学]