正交试验优选当归补血口服液的超滤工艺  

Optimization of Ultrafiltration Technology of Danggui Buxue Oral Liquid by Orthogonal Test

作　　者：余琰[1] 范凌云[1] 魏舒畅[1] 高建德[1] 马立新 

机构地区：[1]甘肃中医学院药学院,兰州730000 [2]兰州佛慈制药股份有限公司,兰州730046

出　　处：《中国药房》2014年第39期3665-3667,共3页China Pharmacy

基　　金：国家自然科学基金资助项目(No.81060345);甘肃省教育厅科研项目(No.1006B-02);甘肃中医学院中青年科研基金资助项目(No.09ZQ-3)

摘　　要：目的:优选当归补血口服液超滤工艺。方法:以黄芪甲苷、总多糖保留率为考察指标,以工作压强、药液温度、药材与提取液质量比为考察因素,采用正交试验优选当归补血口服液的超滤工艺。结果:优选工艺条件为超滤温度30Ⅳ,压强0.75 Mpa,药材与提取液质量比为1∶8。结论:优选出的超滤工艺有效成分保留率高、质量稳定、便于操作。OBJECTIVE： To optimize the ultrafiltration technology of Danggui buxue oral liquid. METHODS： Ultrafiltration technology of Danggui buxue oral liquid was optimized by orthogonal test with the retention rate of astragaloside IV and total polysaccharides as index using pressure intensity, temperature and mass ratio of medicinal materials to extract as factors. RESULTS： The optimal technology was as follows： ultrafiltration temperature 30℃, trans-membrane pressure 0.75 MPa, the ratio of material to water 1 ： 8. CONCLUSIONS： Optimal technology is stable in quality and easy to operation with high retention rate.

关 键 词：正交试验 超滤工艺 当归补血口服液 黄芪甲苷 总多糖 

分 类 号：R285[医药卫生—中药学]