Periostin基因多态性与汉族人群心力衰竭发病的初步研究  

Associations between Periostin gene polymorphisms and heart failure in Chinese Han population

作　　者：纪元[1] 王芳芳[1] 蒋建光[1] 刘志平[1] 周学军[1] 丁志坚[1] 

机构地区：[1]南京医科大学附属常州市第二人民医院心内科,江苏常州213000

出　　处：《南京医科大学学报（自然科学版）》2014年第9期1213-1217,共5页Journal of Nanjing Medical University(Natural Sciences)

基　　金：常州市社会发展科技计划项目(CS20092018)

摘　　要：目的:研究Periostin基因多态性与汉族人群心力衰竭发病的关系。方法:采用聚合酶链反应-限制性片段长度多态法(PCR-RFLP)检测Periostin基因启动子区功能性位点(SNP C-33G)基因型。病例组选自心内科住院的心衰患者464例,对照组选自同期在医院健康体检或住院的正常人群640例。基因型及其他危险因素与心衰关系采用Logistic回归分析。结果:经过年龄、性别、血压、血糖、吸烟、高脂血症等多因素Logistic回归校正,Periostin基因rs3829365位点的CG or GG基因型是心力衰竭的一个独立危险因素;在吸烟的心衰患者中,Periostin C-33G的CG or GG基因型可能起到保护作用。结论:Periostin基因rs3829365位点可能有助于心衰易感性和严重性的判断。Objective：To determine the associations between Periostin gene polymorphisms and heart failure in a Chinese population. Methods：In total,464 patients with heart failure and 640 control individuals were included in this study, rs3829365 was genotyped through PCR and restriction fragment length polymorphism. Multivariate logistic regression was employed to analyze the independent strength of association among clinical parameters,genotypes and heart failure. Results：After adjusting for age, sex, hypertension,diabetes mellitus,smoking and hypertriglyceridemia in multivariate logistic regression,we found that CG or GG of rs3829365 was an independent risk factor for heart failure and that CG or GG of rs3829365 was significantly protective factors for heart failure in patients who smoked. Conclusion：These findings suggest that rs3829365 of Periostin gene may be helpful to determine the susceptibility and severity of heart failure.

关 键 词：心力衰竭 PERIOSTIN rs3829365 单核苷酸多态性 吸烟 

分 类 号：R541.6[医药卫生—心血管疾病]