血清胆固醇与炎症因子和冠心病斑块稳定性的相关性分析  

The predictive role of serum cholesterol and inflammatory factors on coronary plaque stability

作　　者：陈磊磊[1] 王泽穆[1] 陈波[1] 王连生[1] 

机构地区：[1]南京医科大学第一附属医院心脏科,江苏南京210029

出　　处：《南京医科大学学报（自然科学版）》2014年第9期1224-1227,共4页Journal of Nanjing Medical University(Natural Sciences)

基　　金：江苏省中医药局科技项目(LZ13218)

摘　　要：目的：探讨血清胆固醇、炎症因子和冠心病斑块稳定性的相关关系。方法：2013年7月~2014年5月南京医科大学第一附属医院收治的冠心病患者107例,其中55例稳定性心绞痛（stable angina pectoris,SAP）患者为SAP组,52例急性冠状动脉综合征（acute coronary syndrome,ACS）患者为ACS组,并选取相同时期非冠心病患者96例为对照组。主要观察总胆固醇（total cholesterol,TC）、低密度脂蛋白胆固醇（low density lipoprotein cholesterol,LDL-C）、总胆红素（total bilirubin,TBil）、超敏C反应蛋白（high sensitive C reactive protein,hs-CRP）、肿瘤坏死因子（tumor necrosis factor,TNF）-α、白介素（interleukin,IL）-6等炎症因子和斑块稳定性的相关关系。结果：ACS组TC和LDL-C分别为（6.38±1.17）mmol/L和（5.63±1.12）mmol/L,均高于SAP组[TC（4.51±1.06）mmol/L、LDL-C（4.42±1.05）mmol/L],且均高于对照组,差异具有统计学意义（P〈0.05）;ACS组TBil为（6.28±0.74）μmol/L,SAP组TBil为（9.96±1.02）μmol/L,均低于对照组,差异具有统计学意义（P〈0.05）。ACS组Hs-CRP、IL-6和TNF-α分别为（19.06±3.72）mg/L、（57.35±4.14）pg/L和（38.11±2.64）pg/L,均高于SAP组[hs-CRP（11.31±2.15）mg/L、IL-6（29.60±3.08）pg/L和TNF-α（26.82±2.13）pg/L],且均高于对照组,差异具有统计学意义（P〈0.05）。结论：冠心病患者血中TC、LDL-C、IL-6、TNF-α和Hs-CRP等明显增高,并与斑块稳定性呈正相关。Objectlve：To explore the correlation and prediction effect of serum cholesterol inflammatory factors on coronary plaque stability. Methods：Total of 107 patients with coronary heart disease were selected randomly in our hospital from July, 2013 to May, 2014,55 cases of stable angina pectoris patients（SAP） were set as the SAP group,52 cases of acute coronary syndrome（ACS）patients were set as the ACS group. Total cholesterol （TC）, low density lipoprotein cholesterol （LDL-C）, total bilirubiu （TBil）, high sensitive C reactive protein （hs-CRP）,tumor necrosis factor-α （TNF-α）,interleukin-6 （IL-6） and other inflammatory factors were detected. Results： TC and LDL-C of the ACS group were （6.38 ±1.17）mmol/L and （5.63 ±1.12）mmol/L,respectively, higher than those of the SAP group [（4.51 ± 1.06） mmol/L and （4.42 ±1.05）mmol/L,respectively] ,which were higher than those of the control group ,and the differences were significant （P 〈 0.05）. TBil of the ACS group was （6.28± 0.74）μmol/L,and SAP was （9.96 ±1.02）μmol/L,lower than those of the control group, and the differences were significant （P 〈 0.05）. Hs-CRP,IL-6 and TNF-α of the ACS group were （19.06 ± 3.72）mg/L, （57.35 ± 4.14）pg/L and （38.11 ±2.64）pg/L,higher than those of the SAP group [（11.31 ±2.15）mg/L, （29.60 ± 3.08） pg/L and （26.82± 2.13） pg/L, respectively ], and were higher than those of the control group, and the differences were significant （P 〈 0.05）. Conclusion：It is indicated that serum TC,LDL-C,IL-6,TNF-α and Hs-CRP were increased in patients with coronary heart disease ,and were correlative with coronary plaque stability.

关 键 词：炎症因子 冠心病 动脉粥样硬化 

分 类 号：R541.4[医药卫生—心血管疾病]