2-(4'-羧基苯基)咪唑-4,5-二羧酸构筑的稀土(Gd,Dy)MOFs的合成、晶体结构及与DNA作用  

Synthesis,Crystal Structure and DNA Binding of Rare Earth Metal (Gd,Dy)Complexes with 2-(4'-carboxyphenyl)-1H-imidazole-4,5-dicarboxylic Acid

作　　者：石沛[1] 沈伟[1] 管全银[1] 赵国良[1,2] 

机构地区：[1]浙江师范大学化学与生命科学学院,浙江金华321004 [2]浙江师范大学行知学院,浙江金华321004

出　　处：《中国稀土学报》2014年第5期580-588,共9页Journal of the Chinese Society of Rare Earths

基　　金：浙江省自然科学基金项目(LY12B01003)资助

摘　　要：由2-(4'-羧基苯基)咪唑-4,5-二羧酸(HCPhIDC,C12H8N2O6,H4L)和稀土硝酸盐合成了两个稀土配合物[Ln(HCPhIDC)(H2O)2]·3H2O(Ln=Gd(1),Dy(2)),通过元素分析、红外光谱对其进行表征,用单晶X射线衍射方法测定了配合物的晶体结构。结构分析表明:两种晶体属于异质同晶型,同属于三斜晶系,空间群为P1,具有(3,6)-双节点的二维(43)(46·66·83)拓扑结构。测定了配体和配合物与EBDNA体系的作用,结果表明:配体本身对DNA的插入作用很强,而在与稀土离子形成配合物以后,其插入作用反而减弱,这是由于配体本身的分子结构具有良好的平面性,可以很好地插入到DNA的双螺旋结构中,当形成配合物后,整个分子的平面性反而降低了,从而导致插入作用减弱,因此猝灭常数大大降低。Two novel coordination compounds, [ Ln （ HCPhlDC ） （ H20）2 ]· 3H20 （ Ln = Gd （ 1 ）, Dy （ 2 ） ）, （ H4 CPhlDC = 2- （ 4 -carboxyphenyl） -1 H-imidazole-4,5-dicarboxylie acid ） were synthesized by hydrothermal reac- tion and characterized by IR, EA, single crystal X-ray diffraction. The crystal structure analysis revealed that the two complexes belonged to isomorphism, crystallized in the triclinic system, group P1 and displayed 3-connected nodes and 6-connected nodes leads to （43） （4^6·6^6·8^3） nets. The DNA binding of two complexes and the ligand were investigated. The Ksp value shows that the intercalation of the two complexes were in the smaller intensity （ re- lated to the H4CPhIDC ligand） and could release some free EB form EB-DNA, which could be ascribe to the com- pounds inserted into the DNA structure. The interaction of the complexes to the DNA was not so strong related to the H4 CPhIDC ligand itself after complexion, it might be ascribed to that the planarity of the complexes was not so good as the free ligand.

关 键 词：稀土配合物 2-(4'-羧基苯基)咪唑-4 5-二羧酸 晶体结构 DNA作用 

分 类 号：O614.33[理学—无机化学]