老年冠心病患者细胞免疫及体液免疫功能研究  

Clinical studies on cellular immunity and humoral immune function in elderly patients with coronary heart disease

作　　者：张莉[1] 沈俊娴[2] 

机构地区：[1]上海交通大学医学院附属新华医院崇明分院检验科,202150 [2]上海交通大学医学院附属新华医院崇明分院心内科,202150

出　　处：《检验医学与临床》2014年第18期2550-2552,共3页Laboratory Medicine and Clinic

摘　　要：目的探讨老年冠心病(CHD)患者细胞及体液免疫功能与疾病的关系。方法于2010年1月至2013年1月,将127例CHD老年患者分为急性心肌梗死组(AMI组)、不稳定型心绞痛组(UAP组)、稳定型心绞痛组(SAP组)。另选择83例健康老年人纳入对照组。比较各组免疫功能指标。结果 AMI组、UAP组CD3+、CD4+及CD8+淋巴细胞亚群百分比下降,CD4+/CD8+比值升高,IgG、IgE、C3、C4水平升高,与其他研究组比较差异有统计学意义(P<0.05)。结论机体免疫功能失衡与老年CHD的疾病发生、发展关系密切。Objective To investigate the correlation between cellular and humoral immune function and coronary heart disease（CHD）in elderly patients.Methods During Jan.2010 and Jan.2013,a total of 127 elderly patients with CHD were divided into acute myocardial infarction（AMI）group,unstable angina pectoris（UAP）group and stable angina pectoris（SAP）group.Another 83 cases of healthy elderly subjects were enrolled as control group.Indicators of immune function were compared between each group.Results Percentages of CD3^＋,CD4^＋and CD8^＋lymphocyte subsets declined,and levels of CD4^＋/CD8＋ratio,IgG,IgE,C3 and C4increased in AMI group and UAP group,compared with other groups（P〈0.05）.Conclusion Imbalance of immune function could be correlated with occurrence and development of CHD in elderly patients.

关 键 词：冠心病 冠状动脉粥样硬化 细胞免疫 体液免疫 

分 类 号：R541.4[医药卫生—心血管疾病]