急性创伤性凝血病发病机制的研究进展  

Research Progress of Pathogenesis of Acute Traumatic Coagulopathy

作　　者：任小强[1] 陆士奇[1] 肖接承[1] 

机构地区：[1]苏州大学附属第一医院急诊科,江苏苏州215006

出　　处：《医学综述》2014年第18期3294-3296,共3页Medical Recapitulate

摘　　要：急性创伤性凝血病的发病机制十分复杂,涉及凝血系统的多个方面,其主要发病机制尚未完全明确。目前认为急性创伤性凝血病并不是一个简单的消耗性凝血障碍,而是促凝系统、抗凝系统、血小板、纤溶系统及内皮系统动态平衡的紊乱。进一步地改进复苏策略、改善创伤患者预后,需要对急性创伤性凝血病病理生理有更好的理解。The pathogenesis of acute traumatic coagulopath（ATC） is very complicated and it may be attributed to muhiple factors of the coagulation system.However,the pathogenesis of ATC has not been fully identified.The ATC is not merely a consumptive coagulopathy,it＇s currently considered to be an imbalance of the dynamic equilibrium between procoagulant factors,anticoagulant factors,platelets,fibrinolysis and endothelium.Further improvements of damage control resuscitation strategy to improve the prognosis of trauma patients will depend upon a better understanding of the pathophysiology of ATC.

关 键 词：创伤 凝血障碍 病理生理 蛋白C 

分 类 号：R554[医药卫生—血液循环系统疾病] R363.21[医药卫生—内科学]