PEA3转录因子在卵巢癌浸润和转移中的相关研究  

Research of PEA3 Transcription Factor in the Invasion and Metastasis of Ovarian Cancer

作　　者：唐慧子 李菲菲[1] 韩旭[1] 

机构地区：[1]哈尔滨医科大学附属第一医院妇科腔镜科,哈尔滨150001

出　　处：《医学综述》2014年第18期3317-3319,共3页Medical Recapitulate

摘　　要：多瘤病毒增强子激活因子3基因(PEA3)是Ets家族中PEA3亚家族的成员,Ets家族是最大的信号依赖转录调控因子家族之一。Ets家族与人类各种肿瘤的发生、发展密切相关,尤其是参与了肿瘤的浸润和转移过程。卵巢癌是妇科常见的三大恶性肿瘤之一,卵巢癌极易浸润和转移是卵巢癌病死率最高的主要原因之一。肿瘤细胞外基质的降解与新生血管的形成是肿瘤浸润和转移的两个重要环节,其中基质金属蛋白酶(MMPs)、血管内皮生长因子(VEGF)起主要作用,而PEA3转录因子可通过调节MMPs及VEGF来促进卵巢癌的浸润和转移。Polyomavims enhancer activator 3（PEA3）is a member of PEA3 subfamily members in Ets family,which is one of the largest families of signal-dependent transcription factors.Ets family is closely related to variety of tumor＇s occurrence,development in human,especially in tumor invasion and metastasis.Ovarian cancer is one of the three major malignant gynecological tumors,and one of the main reasons of the highest mortality rate of ovarian cancer is that ovarian cancer is the extremely easy invasion and metastasis.Tumor extracellular matrix degradation and angiogenesis are two important steps in the tumor invasion and metastasis,in which matrix metallo-proteinases（MMPs）,vascular endothelial growth factor（VEGF） play major roles.PEA3 transcription factor can promote ovarian carcinoma invasion and metastasis through regulating MMPs and VEGF.

关 键 词：多瘤病毒增强子激活因子3基因 卵巢癌 基质金属蛋白酶 血管内皮生长因子 

分 类 号：R711[医药卫生—妇产科学]