姜黄素对5-Fu化疗大鼠肠黏膜屏障保护作用的实验研究  

Protective Effect of Curcumin on Intestinal Mucosal of Rat after Chemotherapy

作　　者：汪潞[1] 傅婷[1] 来岳标[1] 汪玉琪[1] 陈寒露[1] 王赟[1] 姚庆华[2] 

机构地区：[1]浙江中医药大学第一临床医学院,浙江杭州310053 [2]浙江省中医院,浙江杭州310006

出　　处：《中华中医药学刊》2014年第10期2478-2480,I0017,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：浙江省医药卫生科技计划项目(2011KYB060);黎介寿院士肠道屏障专项基金项目(LJS_201112)

摘　　要：目的:观察姜黄素在利用5-Fu化疗期间对大鼠肠黏膜屏障的保护功能的研究。方法:健康Wister大鼠60只随机分成Control组(20只),5-Fu组(20只,5-氟尿嘧啶),5-Fu+Cur.组(20只,5-氟尿嘧啶+姜黄素),在实验的第2、4、6天监测各组大鼠的体重、内毒素、DAO、D-乳酸水平,第7天处死大鼠后取出大鼠回肠,并在光镜下观察肠黏膜组织结构病理变化。结果:与正常组相比,化疗组的体重明显下降(P<0.05);内毒素、血浆DAO、D-乳酸水平明显增高(P<0.05);肠组织病理学观察可见:肠黏膜明显萎缩,绒毛脱落,并伴有大量炎性细胞浸润。结论:姜黄素对5-Fu化疗期间肠黏膜屏障具有保护作用。Objective：This study was designed to investigate the protective effect of curcumin on chemotherapy- induced intestinal dysfunction in rats. Methods： Sixty healthy Wistar rats were randomly divided into control group（normal saline）,5- FU group and 5- FU ＋ curcumin group. The weight,endotoxin,DAO and D- lactate level were determined during the experiment. The pathological change of intestinal mucosa structure was studied under light microscopy. Results：The curcumin intragastrically obviously reduced 5- FU- induced weight- loss. 5- FU induced dramatic increase of serum endotoxin,D- lactate and D- Amino- Acid Oxidase（DAO） that were significantly reversed by curcumin treatment.Meanwhile,5- FU- induced- damage to intestinal mucosa structure was markedly recovered by curcumin. Conclusions：Curcumin can significantly reverse chemotherapy- induced weight- loss,increase of serum endotoxin,D- lactate and DAO and damage to intestinal mucosa structure. The clinical administration of curcumin may improve chemotherapy- induced intestinal dysfunction,and thus increasing the clinical efficacy of chemotherapy.

关 键 词：姜黄素 化疗 肠黏膜 

分 类 号：R285.5[医药卫生—中药学]