氧化法制备1,2-苯并异噻唑啉-3-酮  

Synthesis of 1,2-benzisothiazolin-3-one by oxidation

作　　者：张可青[1] 任蕊[1] 杨俊伟[1] 李程碑[1] 

机构地区：[1]陕西省石油化工研究设计院,陕西西安710054

出　　处：《应用化工》2014年第9期1637-1639,1643,共4页Applied Chemical Industry

基　　金：延长石油集团科技攻关项目(Ycsy2011Ky-B-112);陕西省石油化工研究设计院青年创新基金项目(2011QCX-011)

摘　　要：以二硫化二苯甲酸为起始原料，经酰胺化后以双氧水为氧化剂，制备1，2-苯并异噻唑啉-3-酮。结果表明，在氧化剂与酰胺的摩尔比为1.2：1，反应时间为3 h，反应温度60℃条件下，反应总收率可达67.7%，产物熔点156~158℃。加入催化剂三乙胺，可加速反应，使得反应时间缩短为2 h，同时氧化反应产率提高为79.2%。1,2-Benzisothiazdin-3-one was prepared from 2,2-dithiobis-benzoic acid by acylation,oxidation with hydrogen peroxide. The result showed that the molar ratio of oxidant and amide was 1. 2： 1,the reac-tion time was 3 h,and the reaction temperature was about 60 ℃ ,and the total yield was 67. 7% ,the melt-ing point product was 156 ~ 158 ℃. The oxidation reaction time was shortened to 2 h by the catalyst tri-ethylamine,and yield of the reaction was increased to 79. 2% as well.

关 键 词：1 2-苯并异噻唑啉-3-酮 杀菌剂 二硫化二苯甲酸 氧化反应 

分 类 号：TQ455.4[化学工程—农药化工]