Toll样受体和其他分子识别受体在固有免疫中的相互作用  

Interaction among Toll-like receptors and other pattern recognition receptors in innate immune

作　　者：胥静[1] 丁力[1] 张俊平[1] 

机构地区：[1]第二军医大学药学院,上海200433

出　　处：《药学实践杂志》2014年第5期324-328,400,共6页Journal of Pharmaceutical Practice

基　　金：国家自然科学基金(81102490)

摘　　要：Toll样受体(Toll-like receptors,TLRs)是参与非特异性免疫(天然免疫)的一类重要蛋白分子,也是连接非特异性免疫和特异性免疫的桥梁。TLRs是一类单次跨膜非催化性的蛋白,可以识别来源于微生物上具有保守结构的分子。当微生物突破机体的物理屏障,如皮肤、黏膜等时,TLRs可以通过识别这些微生物来激活机体的免疫应答反应。除此之外,机体还具有一些其他类型的分子识别模式受体,包括C型凝集素样受体、NOD样受体、视黄酸诱导基因Ⅰ样受体。这些受体都参与了机体免疫调节,它们之间相互作用,使之形成一张极为复杂而精密的网络体系。该综述主要阐明TLRs在机体免疫调节中的作用及其与其他分子识别受体在对病原体识别过程中的交叉相互作用。Toll-like receptors（ TLRs） are germline-encoded pattern recognition receptors（ PRRs） that play a central role in host cell recognition and responses to microbial pathogens. TLRs-mediated recognition of components derived from a wide range of pathogens and their role in the subsequent initiation of innate immune responses is widely accepted,besides,the recent discovery of non-TLR PRRs,such as C-type lectin receptors,NOD-like receptors,and RIG-I-like receptors,suggests that many aspects of innate immunity are more sophisticated and complicated. In this review,we focused on the role cooperated by TLRs in mounting protective immune responses against infection and their crosstalk with other PRRs with respect to pathogen recognition.

关 键 词：TOLL样受体 模式识别受体 固有免疫 

分 类 号：Q939.91[生物学—微生物学]