猪流行性腹泻研究进展  

Progress on Porcine Epidemic Diarrhea

作　　者：牛俊超[1] 黄复深[1] 胡佩佩[1] 

机构地区：[1]湖南农业大学动物医学院,湖南长沙410128

出　　处：《动物医学进展》2014年第10期107-110,共4页Progress In Veterinary Medicine

摘　　要：对猪流行性腹泻的流行病学、病理学和防控研究新进展进行了综述。2013年发现该病在美国和古巴也有流行,乳汁和猫可能在传播中起作用。病毒表达的S蛋白含有该蛋白从内质网、高尔基体运送到细胞膜的信号,参与猪流行性腹泻病毒(PEDV)的复制和PEDV感染引起的神经系统病变。N蛋白参与病毒的复制和转录,通过延长S期抑制肠上皮细胞生长,并且刺激上皮细胞高水平表达IL-8。E蛋白可上调IL-8的表达,但不调节肠上皮细胞的细胞周期。ORF3具多态性,可调节病毒的繁殖。Ⅰ型干扰素对病毒的抑制涉及PLP2蛋白使RIG-I和STING去泛素化干扰RIG-I和STING介导的信号传导过程。槲皮素-7-鼠李糖苷、朝鲜淫羊藿的水提物具有很好的抗病毒活性。PED的研究在以下方面还有待深入,如病毒的侵入、复制机制,疫苗免疫保护机制,抗病毒活性物质在生产实际中的效果。The research progresses on epidemiology,pathogenesis and prevention of PED were summarized.PED was firstly reported in the United States and Cuba in 2013.Milk and cats may play a role in the spread of this dis-ease.S protein expressed by PEDV have signals on carrying S protein from endoplasmic reticulum,Golgi apparatus to membrane.This protein participates in PEDV replication and nervous system pathogenesis caused by PEDV in-fection.N protein involves in virus replication and transcription and inhibites intestinal epithelial cell growth by ex-tending S phase of its cell cycle,and stimulates the high level expression of IL-8 in intestinal epithelial cells.E pro-tein stimulates the high level expression of IL-8 in epithelial cells and does not regulate intestinal epithelial cell growth.ORF3 has polymorphism with adjustment of the virus reproduction.Interferon inhibition on PEDV is done by RIG-I and STING deubiquitylation induced by PLP2.Quercetin-7-rhamnoside,aqueous extract of Korea Epime-dium have good anti-PEDV activity.PED researches remaine to be further in the following respects,for example, mechanism of PEDV viruse invasion and replication,preventive immune responses on PEDV infection and clinical effects of materials with anti-PEDV activity.

关 键 词：猪流行性腹泻 流行病学 发病机制 预防 

分 类 号：S852.659.6[农业科学—基础兽医学]