纤维蛋白粘合剂对犬皮肤切口愈合的影响  

Effect of Fibrin Glue on Healing of Canine Skin Incisions

作　　者：高宇航[1] 陈智华[1] 郭慧琳[2] 王雯慧[1] 范希萍[1] 范彩彩[1] 年聚盆 

机构地区：[1]甘肃农业大学动物医学院,甘肃兰州730070 [2]甘肃省动物疫病预防控制中心,甘肃兰州730046

出　　处：《动物医学进展》2014年第10期122-126,共5页Progress In Veterinary Medicine

基　　金：甘肃省农牧厅生物技术专项项目(GNSW-2011-26)

摘　　要：为探讨自制纤维蛋白粘合剂粘合犬皮肤切口的效果,将其应用于犬皮肤切口,以常规手术缝合切口为对照进行体内粘接效果对比试验。20只健康犬随机分为缝合组与粘合组,分别采用丝线和纤维蛋白粘合剂闭合皮肤切口,观察记录闭合皮肤切口所用时间、切口局部情况、犬整体状态、切口愈合时间、瘢痕宽度及愈合伤口断裂力测定。结果表明,自制纤维蛋白粘合剂粘合皮肤切口所需时间为5s±1s,粘合后的皮肤外观平整,无渗出感染现象,局部疼痛反应轻微,创口愈合需8d^9d,愈合后的瘢痕宽度为0.03mm^0.06mm,伤口断裂力为0.534kg/cm2~0.527kg/cm2。粘合剂组除粘接强度低于缝线组外,其余各项指标均显著优于对照组。To compared the healing process of the canine skin incisions repaired by own produced fibrin glue and interrupted suture with emphasis on studying the effect of fibrin glue.A back incision（Incision 1）and an abdomen incision（Incision 2）both on the midline were performed in every dog.In suture group：the inci-sions were repaired by suture;In adhesive group：the incisions were repaired by fibrin glue.Each group had 10 dogs.The wound closure and healing time,the width of scar and the snap strength of the healing inci-sions were measured,the appearance of the incisions and canine physical indexes were evaluated.The re-sults showed that it spent less time to close the incisions by fibrin glue which took only 4 s to 5 s.The ap-pearance of incisions was smooth with less infiltration and infection,the width of the scars was only 0.03 mm to 0.06 mm while the snap strength of the incisions was 0.534-0.527 kg/cm2 .The healing time of the incisions was fast which cost about 7 d to 8 d and the dogs suffered less pain.In addition to the lack of the bonding strength,Adhesive group showed more advantages than Suture group.

关 键 词：自制纤维蛋白粘合剂 犬皮肤切口 闭合时间 拉伸剪切力 

分 类 号：S857.18[农业科学—临床兽医学]