子宫内膜异位症患者血清及腹腔液sflt-1表达变化及意义  

Expression of vascular endothelial growth factor soluble receptor in the serum and peritoneal fluid of EMs patients

作　　者：李艳芳[1] 史淑红[1] 李腾华 李荣霞[1] 

机构地区：[1]河北医科大学第二医院,石家庄050000

出　　处：《山东医药》2014年第30期4-6,共3页Shandong Medical Journal

基　　金：河北省科技计划项目(12277740)

摘　　要：目的：观察子宫内膜异位症（ EMs）患者血清及腹腔液中血管内皮生长因子可溶性受体（ sflt-1）的表达变化，并探讨其意义。方法 EMs患者48例（病例组），其中Ⅰ～Ⅱ期15例、Ⅲ～Ⅳ期33例，选择同期腹腔镜手术的非EMs患者30例为对照组。采用ELISA法检测两组血清sflt-1、VEGF水平及EMs组腹腔液sflt-1水平，并计算VEGF活性指数。结果 EMs组血清及腹腔液VEGF、sflt-1水平及VEGF活性指数高于对照组，且Ⅲ～Ⅳ期者高于Ⅰ～Ⅱ期者（P均＜0．05）。结论抗血管生成因子表达异常可能参与了EMs的发生发展，sflt-1有望成为新的治疗靶点。Objective To detect the expression of vascular endothelial growth factor soluble receptor （ sflt-1 ） in the serum and peritoneal fluid of the EMs patients and explore it＆#39;s clinical siginificance .Methods A total of 48 EMs patients including 15 ⅠtoⅡstage patients and 33ⅢtoⅣstage patients .Thirty patients cured by the laparoscopic surgery with-out EMS were involved as control group .The expressions of VEGF and sflt-1 in the serum and peritoneal fluid of the two group patients were detected by using ELISA .VEGF activity index was calculated .Results The serum and peritoneal flu-id level of VEGF and sflt-1 as well as VEGF activity index in EMs group were both higher than those of control group （ all P〈0.05）.The serum and peritoneal fluid level of VEGF and sflt-1 as well as VEGF activity index in stage ⅢtoⅣpatients were both higher than those of stage ⅠtoⅡpatients（all P〈0.05）.Conclusions Anti-angiogenic factor expression ab-normalities may be related to the pathogenesis of endometriosis .The sFlt-1 may be a new treatment targets .

关 键 词：子宫内膜异位症 血管内皮生长因子 血管内皮生长因子可溶性受体 

分 类 号：R711.71[医药卫生—妇产科学]